Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Oxana Palesh,1 Luke Peppone,2 Pasquale F Innominato,3&ndash;5 Michelle Janelsins,2 Monica Jeong,1 Lisa Sprod,7 Josee Savard,6 Max Rotatori,1 Shelli Kesler,1 Melinda Telli,1 Karen Mustian21Stanford University School of Medicine, Stanford, CA, USA; 2University of Rochester School of Medicine a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Palesh O, Peppone L, Innominato PF, Janelsins M, Jeong M, Sprod L, Savard J, Rotatori M, Kesler S, Telli M, Mustian K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/7891a088a3694afcbfa0e9a446369695
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7891a088a3694afcbfa0e9a446369695
record_format	dspace
spelling	oai:doaj.org-article:7891a088a3694afcbfa0e9a4463696952021-12-02T04:56:42ZPrevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer1179-1608https://doaj.org/article/7891a088a3694afcbfa0e9a4463696952012-12-01T00:00:00Zhttp://www.dovepress.com/prevalence-putative-mechanisms-and-current-management-of-sleep-problem-a11759https://doaj.org/toc/1179-1608Oxana Palesh,1 Luke Peppone,2 Pasquale F Innominato,3&ndash;5 Michelle Janelsins,2 Monica Jeong,1 Lisa Sprod,7 Josee Savard,6 Max Rotatori,1 Shelli Kesler,1 Melinda Telli,1 Karen Mustian21Stanford University School of Medicine, Stanford, CA, USA; 2University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; 3INSERM, UMRS 776, Biological Rhythms and Cancers, Villejuif, France; 4Faculty of Medicine, Universite Paris Sud, le Kremlin-Bic&ecirc;tre, France; 5APHP, Chronotherapy Unit, Department of Oncology, Paul Brousse Hospital, Villejuif, France; 6Laval University, Quebec, Canada; 7University of North Carolina, Wilmington, NC, USAAbstract: Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associated disruption in circadian rhythm in the development and maintenance of sleep dysregulation in cancer patients during chemotherapy. Various approaches to the management of sleep problems during chemotherapy are discussed with behavioral intervention showing promise. Exercise, including yoga, also appear to be effective and safe at least for subclinical levels of sleep problems in cancer patients. Numerous challenges are associated with conducting research on sleep in cancer patients during chemotherapy treatments and they are discussed in this review. Dedicated intervention trials, methodologically sound and sufficiently powered, are needed to test current and novel treatments of sleep problems in cancer patients receiving chemotherapy. Optimal management of sleep problems in patients with cancer receiving treatment may improve not only the well-being of patients, but also their prognosis given the emerging experimental and clinical evidence suggesting that sleep disruption might adversely impact treatment and recovery from cancer.Keywords: cancer, sleep, chemotherapy, intervention, circadian rhythm, cognitive behavioral therapyPalesh OPeppone LInnominato PFJanelsins MJeong MSprod LSavard JRotatori MKesler STelli MMustian KDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2012, Iss default, Pp 151-162 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Palesh O Peppone L Innominato PF Janelsins M Jeong M Sprod L Savard J Rotatori M Kesler S Telli M Mustian K Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer
description	Oxana Palesh,1 Luke Peppone,2 Pasquale F Innominato,3&ndash;5 Michelle Janelsins,2 Monica Jeong,1 Lisa Sprod,7 Josee Savard,6 Max Rotatori,1 Shelli Kesler,1 Melinda Telli,1 Karen Mustian21Stanford University School of Medicine, Stanford, CA, USA; 2University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; 3INSERM, UMRS 776, Biological Rhythms and Cancers, Villejuif, France; 4Faculty of Medicine, Universite Paris Sud, le Kremlin-Bic&ecirc;tre, France; 5APHP, Chronotherapy Unit, Department of Oncology, Paul Brousse Hospital, Villejuif, France; 6Laval University, Quebec, Canada; 7University of North Carolina, Wilmington, NC, USAAbstract: Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associated disruption in circadian rhythm in the development and maintenance of sleep dysregulation in cancer patients during chemotherapy. Various approaches to the management of sleep problems during chemotherapy are discussed with behavioral intervention showing promise. Exercise, including yoga, also appear to be effective and safe at least for subclinical levels of sleep problems in cancer patients. Numerous challenges are associated with conducting research on sleep in cancer patients during chemotherapy treatments and they are discussed in this review. Dedicated intervention trials, methodologically sound and sufficiently powered, are needed to test current and novel treatments of sleep problems in cancer patients receiving chemotherapy. Optimal management of sleep problems in patients with cancer receiving treatment may improve not only the well-being of patients, but also their prognosis given the emerging experimental and clinical evidence suggesting that sleep disruption might adversely impact treatment and recovery from cancer.Keywords: cancer, sleep, chemotherapy, intervention, circadian rhythm, cognitive behavioral therapy
format	article
author	Palesh O Peppone L Innominato PF Janelsins M Jeong M Sprod L Savard J Rotatori M Kesler S Telli M Mustian K
author_facet	Palesh O Peppone L Innominato PF Janelsins M Jeong M Sprod L Savard J Rotatori M Kesler S Telli M Mustian K
author_sort	Palesh O
title	Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer
title_short	Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer
title_full	Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer
title_fullStr	Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer
title_full_unstemmed	Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer
title_sort	prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/7891a088a3694afcbfa0e9a446369695
work_keys_str_mv	AT palesho prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT pepponel prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT innominatopf prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT janelsinsm prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT jeongm prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT sprodl prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT savardj prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT rotatorim prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT keslers prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT tellim prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer AT mustiank prevalenceputativemechanismsandcurrentmanagementofsleepproblemsduringchemotherapyforcancer
_version_	1718400960535986176

Prevalence, putative mechanisms, and current management of sleep problems during chemotherapy for cancer

Ejemplares similares