Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Celastrol might be useful in treating rheumatoid arthritis in part by inhibiting apoptosis of macrophages; however, systemic toxicity is a concern. Here the authors design celastrol-loaded nanoparticles that release a payload in response to MMP9 cleavage and show these NPs are effective at inducing...

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Autores principales:	Caifeng Deng, Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei, Tao Gong, Zhirong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/789254a8cab5414ba75cd8f2bd03c3f8
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spelling	oai:doaj.org-article:789254a8cab5414ba75cd8f2bd03c3f82021-12-02T18:02:55ZTargeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis10.1038/s41467-021-22454-z2041-1723https://doaj.org/article/789254a8cab5414ba75cd8f2bd03c3f82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22454-zhttps://doaj.org/toc/2041-1723Celastrol might be useful in treating rheumatoid arthritis in part by inhibiting apoptosis of macrophages; however, systemic toxicity is a concern. Here the authors design celastrol-loaded nanoparticles that release a payload in response to MMP9 cleavage and show these NPs are effective at inducing apoptosis of human macrophages in vitro and a therapeutic effect with an adjuvant-induced arthritis model in rats.Caifeng DengQuan ZhangPenghui HeBin ZhouKe HeXun SunGuanghua LeiTao GongZhirong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caifeng Deng Quan Zhang Penghui He Bin Zhou Ke He Xun Sun Guanghua Lei Tao Gong Zhirong Zhang Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
description	Celastrol might be useful in treating rheumatoid arthritis in part by inhibiting apoptosis of macrophages; however, systemic toxicity is a concern. Here the authors design celastrol-loaded nanoparticles that release a payload in response to MMP9 cleavage and show these NPs are effective at inducing apoptosis of human macrophages in vitro and a therapeutic effect with an adjuvant-induced arthritis model in rats.
format	article
author	Caifeng Deng Quan Zhang Penghui He Bin Zhou Ke He Xun Sun Guanghua Lei Tao Gong Zhirong Zhang
author_facet	Caifeng Deng Quan Zhang Penghui He Bin Zhou Ke He Xun Sun Guanghua Lei Tao Gong Zhirong Zhang
author_sort	Caifeng Deng
title	Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
title_short	Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
title_full	Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
title_fullStr	Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
title_full_unstemmed	Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
title_sort	targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/789254a8cab5414ba75cd8f2bd03c3f8
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_version_	1718378814813241344

Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

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