Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliar...

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Autores principales:	Linh T. Vuong, Carlo Iomini, Sophie Balmer, Davide Esposito, Stuart A. Aaronson, Marek Mlodzik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7893223fd93f4dcbba5c114000984a9d
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spelling	oai:doaj.org-article:7893223fd93f4dcbba5c114000984a9d2021-12-02T16:49:33ZKinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling10.1038/s41467-018-07605-z2041-1723https://doaj.org/article/7893223fd93f4dcbba5c114000984a9d2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07605-zhttps://doaj.org/toc/2041-1723IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliary role.Linh T. VuongCarlo IominiSophie BalmerDavide EspositoStuart A. AaronsonMarek MlodzikNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linh T. Vuong Carlo Iomini Sophie Balmer Davide Esposito Stuart A. Aaronson Marek Mlodzik Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling
description	IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliary role.
format	article
author	Linh T. Vuong Carlo Iomini Sophie Balmer Davide Esposito Stuart A. Aaronson Marek Mlodzik
author_facet	Linh T. Vuong Carlo Iomini Sophie Balmer Davide Esposito Stuart A. Aaronson Marek Mlodzik
author_sort	Linh T. Vuong
title	Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling
title_short	Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling
title_full	Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling
title_fullStr	Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling
title_full_unstemmed	Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling
title_sort	kinesin-2 and ift-a act as a complex promoting nuclear localization of β-catenin during wnt signalling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7893223fd93f4dcbba5c114000984a9d
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Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

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