Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases

Abstract Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. However, the rise in lifespan leads to unprecedented increases in both the number and t...

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Autores principales:	Shuqi Du, Hui Zheng
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Aging FoxO Age-related disease Type 2 diabetes mellitus Alzheimer’s disease Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/789521ad10634420925a4b0d92e23b3b
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id	oai:doaj.org-article:789521ad10634420925a4b0d92e23b3b
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spelling	oai:doaj.org-article:789521ad10634420925a4b0d92e23b3b2021-11-08T11:03:29ZRole of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases10.1186/s13578-021-00700-72045-3701https://doaj.org/article/789521ad10634420925a4b0d92e23b3b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13578-021-00700-7https://doaj.org/toc/2045-3701Abstract Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. However, the rise in lifespan leads to unprecedented increases in both the number and the percentage of individuals 65 years and older, accompanied by the increased incidences of age-related diseases such as type 2 diabetes mellitus and Alzheimer’s disease. FoxO transcription factors are evolutionarily conserved molecules that play critical roles in diverse biological processes, in particular aging and metabolism. Their dysfunction is often found in the pathogenesis of many age-related diseases. Here, we summarize the signaling pathways and cellular functions of FoxO proteins. We also review the complex role of FoxO in aging and age-related diseases, with focus on type 2 diabetes and Alzheimer’s disease and discuss the possibility of FoxO as a molecular link between aging and disease risks.Shuqi DuHui ZhengBMCarticleAgingFoxOAge-related diseaseType 2 diabetes mellitusAlzheimer’s diseaseBiotechnologyTP248.13-248.65Biology (General)QH301-705.5BiochemistryQD415-436ENCell & Bioscience, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aging FoxO Age-related disease Type 2 diabetes mellitus Alzheimer’s disease Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
spellingShingle	Aging FoxO Age-related disease Type 2 diabetes mellitus Alzheimer’s disease Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436 Shuqi Du Hui Zheng Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
description	Abstract Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. However, the rise in lifespan leads to unprecedented increases in both the number and the percentage of individuals 65 years and older, accompanied by the increased incidences of age-related diseases such as type 2 diabetes mellitus and Alzheimer’s disease. FoxO transcription factors are evolutionarily conserved molecules that play critical roles in diverse biological processes, in particular aging and metabolism. Their dysfunction is often found in the pathogenesis of many age-related diseases. Here, we summarize the signaling pathways and cellular functions of FoxO proteins. We also review the complex role of FoxO in aging and age-related diseases, with focus on type 2 diabetes and Alzheimer’s disease and discuss the possibility of FoxO as a molecular link between aging and disease risks.
format	article
author	Shuqi Du Hui Zheng
author_facet	Shuqi Du Hui Zheng
author_sort	Shuqi Du
title	Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
title_short	Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
title_full	Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
title_fullStr	Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
title_full_unstemmed	Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
title_sort	role of foxo transcription factors in aging and age-related metabolic and neurodegenerative diseases
publisher	BMC
publishDate	2021
url	https://doaj.org/article/789521ad10634420925a4b0d92e23b3b
work_keys_str_mv	AT shuqidu roleoffoxotranscriptionfactorsinagingandagerelatedmetabolicandneurodegenerativediseases AT huizheng roleoffoxotranscriptionfactorsinagingandagerelatedmetabolicandneurodegenerativediseases
_version_	1718442439230881792

Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases

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