LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME

Metabolic syndrome is a chronic subclinical inflammation. Published data on the immune state in metabolic syndrome are inconsistent, and, moreover, the gender features of metabolic syndrome are not described in details. The purpose of the study was to determine subpopulation profile of peripheral ly...

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Autores principales:	V. A. Sumerkina, L. F. Telesheva, E. S. Golovneva, S. V. Kvyatkovskaya, E. E. Dvorchik
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	lymphocyte subpopulations abdominal obesity hypertension Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/789531c183c94423a225b13778b03d0f
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spelling	oai:doaj.org-article:789531c183c94423a225b13778b03d0f2021-11-18T08:03:45ZLYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME1563-06252313-741X10.15789/1563-0625-2016-2-187-192https://doaj.org/article/789531c183c94423a225b13778b03d0f2016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1003https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMetabolic syndrome is a chronic subclinical inflammation. Published data on the immune state in metabolic syndrome are inconsistent, and, moreover, the gender features of metabolic syndrome are not described in details. The purpose of the study was to determine subpopulation profile of peripheral lymphocytes in young men with metabolic syndrome, as well as in cases of combined abdominal obesity and hypertension. The study included seventy-seven men aged 20-45 years. The men were divided into four groups matched by age: Group 1 represented healthy controls; group 2 included male patients with isolated abdominal obesity; group 3 consisted of males with a combination of abdominal obesity and hypertension; group 4, males with metabolic syndrome. The major lymphocyte subpopulations were isolated and analyzed by flow cytometry, i.e. T lymphocytes, T helpers, T-cytotoxic cells, TNK-lymphocytes, NK-cells, B-cells, as well as CD3+CD25+ and CD3+HLADR+ lymphocytes. In male patients with isolated abdominal obesity, we revealed increased relative contents of T lymphocytes, and increased proportion of the cells with CD3+CD8+, CD3+CD25+ phenotypes and higher B-cell numbers. A combination of abdominal obesity with hypertension in men was characterized by decreased ratio of T-helper/T-cytotoxic lymphocytes, due to reduced relative contents of CD3+CD4+ cells and increase in CD3+CD8+ lymphocytes. The numbers of T-helper cells in this group were significantly lower than in controls and among patients with isolated abdominal obesity. The number of T-cells with CD3+HLADR+ phenotype proved to be 2-fold higher than in the group of healthy male controls.V. A. SumerkinaL. F. TeleshevaE. S. GolovnevaS. V. KvyatkovskayaE. E. DvorchikSPb RAACIarticlelymphocyte subpopulationsabdominal obesityhypertensionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 2, Pp 187-192 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocyte subpopulations abdominal obesity hypertension Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocyte subpopulations abdominal obesity hypertension Immunologic diseases. Allergy RC581-607 V. A. Sumerkina L. F. Telesheva E. S. Golovneva S. V. Kvyatkovskaya E. E. Dvorchik LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME
description	Metabolic syndrome is a chronic subclinical inflammation. Published data on the immune state in metabolic syndrome are inconsistent, and, moreover, the gender features of metabolic syndrome are not described in details. The purpose of the study was to determine subpopulation profile of peripheral lymphocytes in young men with metabolic syndrome, as well as in cases of combined abdominal obesity and hypertension. The study included seventy-seven men aged 20-45 years. The men were divided into four groups matched by age: Group 1 represented healthy controls; group 2 included male patients with isolated abdominal obesity; group 3 consisted of males with a combination of abdominal obesity and hypertension; group 4, males with metabolic syndrome. The major lymphocyte subpopulations were isolated and analyzed by flow cytometry, i.e. T lymphocytes, T helpers, T-cytotoxic cells, TNK-lymphocytes, NK-cells, B-cells, as well as CD3+CD25+ and CD3+HLADR+ lymphocytes. In male patients with isolated abdominal obesity, we revealed increased relative contents of T lymphocytes, and increased proportion of the cells with CD3+CD8+, CD3+CD25+ phenotypes and higher B-cell numbers. A combination of abdominal obesity with hypertension in men was characterized by decreased ratio of T-helper/T-cytotoxic lymphocytes, due to reduced relative contents of CD3+CD4+ cells and increase in CD3+CD8+ lymphocytes. The numbers of T-helper cells in this group were significantly lower than in controls and among patients with isolated abdominal obesity. The number of T-cells with CD3+HLADR+ phenotype proved to be 2-fold higher than in the group of healthy male controls.
format	article
author	V. A. Sumerkina L. F. Telesheva E. S. Golovneva S. V. Kvyatkovskaya E. E. Dvorchik
author_facet	V. A. Sumerkina L. F. Telesheva E. S. Golovneva S. V. Kvyatkovskaya E. E. Dvorchik
author_sort	V. A. Sumerkina
title	LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME
title_short	LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME
title_full	LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME
title_fullStr	LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME
title_full_unstemmed	LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME
title_sort	lymphocyte subpopulation profile in young men with metabolic syndrome
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/789531c183c94423a225b13778b03d0f
work_keys_str_mv	AT vasumerkina lymphocytesubpopulationprofileinyoungmenwithmetabolicsyndrome AT lftelesheva lymphocytesubpopulationprofileinyoungmenwithmetabolicsyndrome AT esgolovneva lymphocytesubpopulationprofileinyoungmenwithmetabolicsyndrome AT svkvyatkovskaya lymphocytesubpopulationprofileinyoungmenwithmetabolicsyndrome AT eedvorchik lymphocytesubpopulationprofileinyoungmenwithmetabolicsyndrome
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LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME

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