A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

Lactic acid (LA) is an important organic acid with broad industrial applications. Considered as an environmentally friendly alternative to petroleum-based plastic with a wide range of applications, polylactic acid has generated a great deal of interest and therefore the demand for optically pure <...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shiyong Huang, Yanfen Xue, Bo Yu, Limin Wang, Cheng Zhou, Yanhe Ma
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lactic acid polylactic acid microbial production renewable resource clean fermentation metabolic engineering Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/7895e0f43c444c57a74f51e9a4da53de
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7895e0f43c444c57a74f51e9a4da53de
record_format	dspace
spelling	oai:doaj.org-article:7895e0f43c444c57a74f51e9a4da53de2021-11-11T18:27:32ZA Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids10.3390/molecules262164461420-3049https://doaj.org/article/7895e0f43c444c57a74f51e9a4da53de2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6446https://doaj.org/toc/1420-3049Lactic acid (LA) is an important organic acid with broad industrial applications. Considered as an environmentally friendly alternative to petroleum-based plastic with a wide range of applications, polylactic acid has generated a great deal of interest and therefore the demand for optically pure <span style="font-variant: small-caps;">l</span>- or <span style="font-variant: small-caps;">d</span>-lactic acid has increased accordingly. Microbial fermentation is the industrial route for LA production. LA bacteria and certain genetic engineering bacteria are widely used for LA production. Although some fungi, such as <i>Saccharomyces cerevisiae</i>, are not natural LA producers, they have recently received increased attention for LA production because of their acid tolerance. The main challenge for LA bioproduction is the high cost of substrates. The development of LA production from cost-effective biomasses is a potential solution to reduce the cost of LA production. This review examined and discussed recent progress in optically pure <span style="font-variant: small-caps;">l</span>-lactic acid and optically pure <span style="font-variant: small-caps;">d</span>-lactic acid fermentation. The utilization of inexpensive substrates is also focused on. Additionally, for PLA production, a complete biological process by one-step fermentation from renewable resources is also currently being developed by metabolically engineered bacteria. We also summarize the strategies and procedures for metabolically engineering microorganisms producing PLA. In addition, there exists some challenges to efficiently produce PLA, therefore strategies to overcome these challenges through metabolic engineering combined with enzyme engineering are also discussed.Shiyong HuangYanfen XueBo YuLimin WangCheng ZhouYanhe MaMDPI AGarticlelactic acidpolylactic acidmicrobial productionrenewable resourceclean fermentationmetabolic engineeringOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6446, p 6446 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lactic acid polylactic acid microbial production renewable resource clean fermentation metabolic engineering Organic chemistry QD241-441
spellingShingle	lactic acid polylactic acid microbial production renewable resource clean fermentation metabolic engineering Organic chemistry QD241-441 Shiyong Huang Yanfen Xue Bo Yu Limin Wang Cheng Zhou Yanhe Ma A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids
description	Lactic acid (LA) is an important organic acid with broad industrial applications. Considered as an environmentally friendly alternative to petroleum-based plastic with a wide range of applications, polylactic acid has generated a great deal of interest and therefore the demand for optically pure <span style="font-variant: small-caps;">l</span>- or <span style="font-variant: small-caps;">d</span>-lactic acid has increased accordingly. Microbial fermentation is the industrial route for LA production. LA bacteria and certain genetic engineering bacteria are widely used for LA production. Although some fungi, such as <i>Saccharomyces cerevisiae</i>, are not natural LA producers, they have recently received increased attention for LA production because of their acid tolerance. The main challenge for LA bioproduction is the high cost of substrates. The development of LA production from cost-effective biomasses is a potential solution to reduce the cost of LA production. This review examined and discussed recent progress in optically pure <span style="font-variant: small-caps;">l</span>-lactic acid and optically pure <span style="font-variant: small-caps;">d</span>-lactic acid fermentation. The utilization of inexpensive substrates is also focused on. Additionally, for PLA production, a complete biological process by one-step fermentation from renewable resources is also currently being developed by metabolically engineered bacteria. We also summarize the strategies and procedures for metabolically engineering microorganisms producing PLA. In addition, there exists some challenges to efficiently produce PLA, therefore strategies to overcome these challenges through metabolic engineering combined with enzyme engineering are also discussed.
format	article
author	Shiyong Huang Yanfen Xue Bo Yu Limin Wang Cheng Zhou Yanhe Ma
author_facet	Shiyong Huang Yanfen Xue Bo Yu Limin Wang Cheng Zhou Yanhe Ma
author_sort	Shiyong Huang
title	A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids
title_short	A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids
title_full	A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids
title_fullStr	A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids
title_full_unstemmed	A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids
title_sort	review of the recent developments in the bioproduction of polylactic acid and its precursors optically pure lactic acids
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7895e0f43c444c57a74f51e9a4da53de
work_keys_str_mv	AT shiyonghuang areviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT yanfenxue areviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT boyu areviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT liminwang areviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT chengzhou areviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT yanhema areviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT shiyonghuang reviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT yanfenxue reviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT boyu reviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT liminwang reviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT chengzhou reviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids AT yanhema reviewoftherecentdevelopmentsinthebioproductionofpolylacticacidanditsprecursorsopticallypurelacticacids
_version_	1718431829562753024

A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

Ejemplares similares