Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs

Abstract High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their enco...

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Autores principales:	Mengnan Zhang, Lilya V. Matyunina, L. DeEtte Walker, Weixuan Chen, Haopeng Xiao, Benedict B. Benigno, Ronghu Wu, John F. McDonald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7897ad282e104afabe0c3c6fd98e370c
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spelling	oai:doaj.org-article:7897ad282e104afabe0c3c6fd98e370c2021-12-02T11:52:43ZEvidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs10.1038/s41598-017-08502-z2045-2322https://doaj.org/article/7897ad282e104afabe0c3c6fd98e370c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08502-zhttps://doaj.org/toc/2045-2322Abstract High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their encoded proteins. We systematically compared the expression of 4436 genes on the RNA and protein levels between discrete tumor samples collected from the ovary and from the omentum of the same OC patient. The overall correlation between global changes in levels of mRNA and their encoding proteins is low (r = 0.38). The majority of differences are on the protein level with no corresponding change on the mRNA level. Indirect and direct evidence indicates that a significant fraction of the differences may be mediated by microRNAs.Mengnan ZhangLilya V. MatyuninaL. DeEtte WalkerWeixuan ChenHaopeng XiaoBenedict B. BenignoRonghu WuJohn F. McDonaldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengnan Zhang Lilya V. Matyunina L. DeEtte Walker Weixuan Chen Haopeng Xiao Benedict B. Benigno Ronghu Wu John F. McDonald Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
description	Abstract High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their encoded proteins. We systematically compared the expression of 4436 genes on the RNA and protein levels between discrete tumor samples collected from the ovary and from the omentum of the same OC patient. The overall correlation between global changes in levels of mRNA and their encoding proteins is low (r = 0.38). The majority of differences are on the protein level with no corresponding change on the mRNA level. Indirect and direct evidence indicates that a significant fraction of the differences may be mediated by microRNAs.
format	article
author	Mengnan Zhang Lilya V. Matyunina L. DeEtte Walker Weixuan Chen Haopeng Xiao Benedict B. Benigno Ronghu Wu John F. McDonald
author_facet	Mengnan Zhang Lilya V. Matyunina L. DeEtte Walker Weixuan Chen Haopeng Xiao Benedict B. Benigno Ronghu Wu John F. McDonald
author_sort	Mengnan Zhang
title	Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
title_short	Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
title_full	Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
title_fullStr	Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
title_full_unstemmed	Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs
title_sort	evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of mirnas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7897ad282e104afabe0c3c6fd98e370c
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Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs

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