Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis

Abstract Background Surgery remains the major treatment for early breast cancer (BC), but surgery itself is also a trauma which might induce alterations in lipid metabolism. The aim of this study was to investigate the changes in lipid profiles and to explore factors associated with lipid changes pr...

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Autores principales:	Tao He, Zhu Wang, Yunhao Wu, Xinyi Zhang, Xu Li, Jiayuan Li, Liang Du, Jie Chen, Qing Lv
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Breast cancer Surgery Dyslipidemia RD1-811
Acceso en línea:	https://doaj.org/article/789902dba79f44c182158d2594a83f77
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spelling	oai:doaj.org-article:789902dba79f44c182158d2594a83f772021-11-14T12:09:28ZLipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis10.1186/s12893-021-01396-91471-2482https://doaj.org/article/789902dba79f44c182158d2594a83f772021-11-01T00:00:00Zhttps://doi.org/10.1186/s12893-021-01396-9https://doaj.org/toc/1471-2482Abstract Background Surgery remains the major treatment for early breast cancer (BC), but surgery itself is also a trauma which might induce alterations in lipid metabolism. The aim of this study was to investigate the changes in lipid profiles and to explore factors associated with lipid changes pre- and postoperation. Methods We retrospectively analyzed the pre- and postoperative serum lipid profiles of 1934 BC patients. Results The levels of triglycerides (TG) (p < 0.001) and low-density lipoprotein cholesterol (LDL) (p < 0.001) were significantly elevated after surgery, while the levels of high-density lipoprotein cholesterol (HDL) (p < 0.001) were significantly decreased. After surgery, 27.76% of patients with preoperative ortholiposis developed dyslipidemia. Postmenopausal BC patients had a higher incidence of dyslipidemia (32.31%) after surgery than premenopausal BC patients (26.07%; p = 0.041). Additionally, patients with BMI > 24 (34.92%) had a higher incidence of dyslipidemia than patients with BMI ≤ 24 (24.84%; p = 0.001). Moreover, the magnitudes of the TG increase (p < 0.001), cholesterol (TC) increase (p = 0.013) and LDL increase (p = 0.015) in the premenopausal group were all greater than those in the postmenopausal group. After adjusting for multiple baseline covariates, preoperative hyperlipidemia and progesterone receptor (PR)-positive status were significantly associated with elevated TG, TC and LDL levels after surgery. Conclusions Serum lipid profiles of BC patients may increase after surgery, especially premenopausal patients. Additionally, postmenopausal and overweight patients may have a higher risk of being diagnosed with dyslipidemia after surgery. Therefore, lipid monitoring, dyslipidemia prevention and corresponding interventions should be taken into consideration during the perioperative period.Tao HeZhu WangYunhao WuXinyi ZhangXu LiJiayuan LiLiang DuJie ChenQing LvBMCarticleBreast cancerSurgeryDyslipidemiaSurgeryRD1-811ENBMC Surgery, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast cancer Surgery Dyslipidemia Surgery RD1-811
spellingShingle	Breast cancer Surgery Dyslipidemia Surgery RD1-811 Tao He Zhu Wang Yunhao Wu Xinyi Zhang Xu Li Jiayuan Li Liang Du Jie Chen Qing Lv Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
description	Abstract Background Surgery remains the major treatment for early breast cancer (BC), but surgery itself is also a trauma which might induce alterations in lipid metabolism. The aim of this study was to investigate the changes in lipid profiles and to explore factors associated with lipid changes pre- and postoperation. Methods We retrospectively analyzed the pre- and postoperative serum lipid profiles of 1934 BC patients. Results The levels of triglycerides (TG) (p < 0.001) and low-density lipoprotein cholesterol (LDL) (p < 0.001) were significantly elevated after surgery, while the levels of high-density lipoprotein cholesterol (HDL) (p < 0.001) were significantly decreased. After surgery, 27.76% of patients with preoperative ortholiposis developed dyslipidemia. Postmenopausal BC patients had a higher incidence of dyslipidemia (32.31%) after surgery than premenopausal BC patients (26.07%; p = 0.041). Additionally, patients with BMI > 24 (34.92%) had a higher incidence of dyslipidemia than patients with BMI ≤ 24 (24.84%; p = 0.001). Moreover, the magnitudes of the TG increase (p < 0.001), cholesterol (TC) increase (p = 0.013) and LDL increase (p = 0.015) in the premenopausal group were all greater than those in the postmenopausal group. After adjusting for multiple baseline covariates, preoperative hyperlipidemia and progesterone receptor (PR)-positive status were significantly associated with elevated TG, TC and LDL levels after surgery. Conclusions Serum lipid profiles of BC patients may increase after surgery, especially premenopausal patients. Additionally, postmenopausal and overweight patients may have a higher risk of being diagnosed with dyslipidemia after surgery. Therefore, lipid monitoring, dyslipidemia prevention and corresponding interventions should be taken into consideration during the perioperative period.
format	article
author	Tao He Zhu Wang Yunhao Wu Xinyi Zhang Xu Li Jiayuan Li Liang Du Jie Chen Qing Lv
author_facet	Tao He Zhu Wang Yunhao Wu Xinyi Zhang Xu Li Jiayuan Li Liang Du Jie Chen Qing Lv
author_sort	Tao He
title	Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
title_short	Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
title_full	Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
title_fullStr	Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
title_full_unstemmed	Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
title_sort	lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/789902dba79f44c182158d2594a83f77
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Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis

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