In silico analysis of Glanzmann variants of Calf-1 domain of αIIbβ3 integrin revealed dynamic allosteric effect
Abstract Integrin αIIbβ3 mediates platelet aggregation and thrombus formation. In a rare hereditary bleeding disorder, Glanzmann thrombasthenia (GT), αIIbβ3 expression / function are impaired. The impact of deleterious missense mutations on the complex structure remains unclear. Long independent mol...
Guardado en:
Autores principales: | Matthieu Goguet, Tarun Jairaj Narwani, Rachel Petermann, Vincent Jallu, Alexandre G. de Brevern |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/78993e28dd484f5d8a86ac350d7f3950 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Modeling and molecular dynamics of HPA-1a and -1b polymorphisms: effects on the structure of the β3 subunit of the αIIbβ3 integrin.
por: Vincent Jallu, et al.
Publicado: (2012) -
The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.
por: Shigenori Honda, et al.
Publicado: (2013) -
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
por: Xiaohong Ruby Xu, et al.
Publicado: (2018) -
Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation
por: Klytaimnistra Kiouptsi, et al.
Publicado: (2017) -
Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction.
por: Daniel K Shanley, et al.
Publicado: (2013)