Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System

Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit, Department of Pharmacy, College...

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Autores principales:	Yehualashet AS, Yikna BB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	gut micro biota intestinal flora microbial ecosystem diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/789c137c50bb43d68cd5469387b649bd
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spelling	oai:doaj.org-article:789c137c50bb43d68cd5469387b649bd2021-12-02T14:51:56ZMicrobial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System1178-7007https://doaj.org/article/789c137c50bb43d68cd5469387b649bd2021-04-01T00:00:00Zhttps://www.dovepress.com/microbial-ecosystem-in-diabetes-mellitus-consideration-of-the-gastroin-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, PO Box 445, Debre Berhan, EthiopiaTel +251 935450290Email awgshewa@gmail.comAbstract: Intestinal microbiota is established to be a crucial element in the control of human health, and keeping the symbiotic relationship between the human body and intestinal microbes will have paramount importance. A number of investigations illustrated that many chronic diseases are associated with intestinal micro-ecological disorders implying intestinal floras as an important component among the environmental factors, and perturbations in their composition are correlated with metabolic disorders, including obesity and diabetes mellitus (DM). Increased evidence suggests that alterations in the gut microbial ecosystem have been involved in part in the pathogenesis of both type 1 and type 2 DM. Short chain fatty acids (SCFAs), derived from microbiota, have been studied for their potential action in modulating CNS, gut barrier axis, and the immune system as a promising mechanism for the observed protective effects on diabetes pathogenesis. Besides, the role of bile acid (BA) stimulated receptors to have a significant role in liver metabolism, and pathophysiology of liver-based metabolic diseases has also been investigated. In the current review, we will try to summarize the correlation between intestinal microbiota and diabetes considering the existing current evidence revealing the role of gut microbiota in onset and disease progression.Keywords: gut microbiota, intestinal flora, microbial ecosystem, diabetes mellitusYehualashet ASYikna BBDove Medical Pressarticlegut micro biotaintestinal floramicrobial ecosystemdiabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1841-1854 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut micro biota intestinal flora microbial ecosystem diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	gut micro biota intestinal flora microbial ecosystem diabetes mellitus Specialties of internal medicine RC581-951 Yehualashet AS Yikna BB Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
description	Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, EthiopiaCorrespondence: Awgichew Shewasinad YehualashetPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, PO Box 445, Debre Berhan, EthiopiaTel +251 935450290Email awgshewa@gmail.comAbstract: Intestinal microbiota is established to be a crucial element in the control of human health, and keeping the symbiotic relationship between the human body and intestinal microbes will have paramount importance. A number of investigations illustrated that many chronic diseases are associated with intestinal micro-ecological disorders implying intestinal floras as an important component among the environmental factors, and perturbations in their composition are correlated with metabolic disorders, including obesity and diabetes mellitus (DM). Increased evidence suggests that alterations in the gut microbial ecosystem have been involved in part in the pathogenesis of both type 1 and type 2 DM. Short chain fatty acids (SCFAs), derived from microbiota, have been studied for their potential action in modulating CNS, gut barrier axis, and the immune system as a promising mechanism for the observed protective effects on diabetes pathogenesis. Besides, the role of bile acid (BA) stimulated receptors to have a significant role in liver metabolism, and pathophysiology of liver-based metabolic diseases has also been investigated. In the current review, we will try to summarize the correlation between intestinal microbiota and diabetes considering the existing current evidence revealing the role of gut microbiota in onset and disease progression.Keywords: gut microbiota, intestinal flora, microbial ecosystem, diabetes mellitus
format	article
author	Yehualashet AS Yikna BB
author_facet	Yehualashet AS Yikna BB
author_sort	Yehualashet AS
title	Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
title_short	Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
title_full	Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
title_fullStr	Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
title_full_unstemmed	Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
title_sort	microbial ecosystem in diabetes mellitus: consideration of the gastrointestinal system
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/789c137c50bb43d68cd5469387b649bd
work_keys_str_mv	AT yehualashetas microbialecosystemindiabetesmellitusconsiderationofthegastrointestinalsystem AT yiknabb microbialecosystemindiabetesmellitusconsiderationofthegastrointestinalsystem
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Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System

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