The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population

Robert Paul1, Lorrie Henry2, Stuart M Grieve3, Thomas J Guilmette2,4, Raymond Niaura4, Richard Bryant5, Steven Bruce1, Leanne M Williams3,6, Clark C Richard7, Ronald A Cohen4, Evian Gordon3,71University of Missouri, St. Louis, St. Louis, MO, USA; 2Providence College, Providence, RI, USA; 3The Brain...

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Autores principales:	Robert Paul, Lorrie Henry, Stuart M Grieve, Thomas J Guilmette, Raymond Niaura, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/78a08fa529a247da81ef5c38658d86e5
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spelling	oai:doaj.org-article:78a08fa529a247da81ef5c38658d86e52021-12-02T04:31:34ZThe relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population1176-63281178-2021https://doaj.org/article/78a08fa529a247da81ef5c38658d86e52008-03-01T00:00:00Zhttp://www.dovepress.com/the-relationship-between-early-life-stress-and-microstructural-integri-a983https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Robert Paul1, Lorrie Henry2, Stuart M Grieve3, Thomas J Guilmette2,4, Raymond Niaura4, Richard Bryant5, Steven Bruce1, Leanne M Williams3,6, Clark C Richard7, Ronald A Cohen4, Evian Gordon3,71University of Missouri, St. Louis, St. Louis, MO, USA; 2Providence College, Providence, RI, USA; 3The Brain Resource International Database, The Brain Resource Company, Ultimo, NSW, Australia; 4Brown Medical School, Department of Psychiatry, Providence, RI, USA; 5School of Psychology, University of New South Wales, Sydney, NSW, Australia; 6Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia; 7Cognitive Neuroscience Laboratory and School of Psychology, Flinders University, Adelaide, SA, AustraliaBackground: Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain.Methods: In the present study we evaluated this relationship in healthy non-clinical participants using diffusion tensor imaging (DTI) and self-reported history of ELS.Results: Regression analyses revealed significant reductions in fractional anisotropy (FA) within the genu of the corpus callosum among those exposed to the greatest number of early life stressors, suggesting reduced microstructural integrity associated with increased ELS. These effects were most pronounced in the genu of the corpus callosum compared to the body and splenium, and were evident for females rather than males despite no differences in total ELS exposure between the sexes. In addition, a further comparison of those participants who were exposed to no ELS vs. three or more ELS events revealed lower FA in the genu of the corpus callosum among the ELS-exposed group, with trends of FA reduction in the body and the whole corpus callosum. By contrast, there were no relationships between ELS and volumetric analysis of the CC regions. The two groups did not differ significantly on measures of current depression, stress or anxiety.Conclusion: Our results reveal that greater exposure to ELS is associated with microstructural alterations in the white matter in the absence of significant volumetric changes. Importantly, our results indicate that exposure to ELS is associated with abnormalities on DTI despite the absence of clinically significant psychiatric symptoms. Future studies are needed to determine whether specific types of ELS are more likely to impact brain structure and function. Robert PaulLorrie HenryStuart M GrieveThomas J GuilmetteRaymond Niauraet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 193-201 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Robert Paul Lorrie Henry Stuart M Grieve Thomas J Guilmette Raymond Niaura et al The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population
description	Robert Paul1, Lorrie Henry2, Stuart M Grieve3, Thomas J Guilmette2,4, Raymond Niaura4, Richard Bryant5, Steven Bruce1, Leanne M Williams3,6, Clark C Richard7, Ronald A Cohen4, Evian Gordon3,71University of Missouri, St. Louis, St. Louis, MO, USA; 2Providence College, Providence, RI, USA; 3The Brain Resource International Database, The Brain Resource Company, Ultimo, NSW, Australia; 4Brown Medical School, Department of Psychiatry, Providence, RI, USA; 5School of Psychology, University of New South Wales, Sydney, NSW, Australia; 6Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia; 7Cognitive Neuroscience Laboratory and School of Psychology, Flinders University, Adelaide, SA, AustraliaBackground: Previous studies have examined the impact of early life stress (ELS) on the gross morphometry of brain regions, including the corpus callosum. However, studies have not examined the relationship between ELS and the microstructural integrity of the brain.Methods: In the present study we evaluated this relationship in healthy non-clinical participants using diffusion tensor imaging (DTI) and self-reported history of ELS.Results: Regression analyses revealed significant reductions in fractional anisotropy (FA) within the genu of the corpus callosum among those exposed to the greatest number of early life stressors, suggesting reduced microstructural integrity associated with increased ELS. These effects were most pronounced in the genu of the corpus callosum compared to the body and splenium, and were evident for females rather than males despite no differences in total ELS exposure between the sexes. In addition, a further comparison of those participants who were exposed to no ELS vs. three or more ELS events revealed lower FA in the genu of the corpus callosum among the ELS-exposed group, with trends of FA reduction in the body and the whole corpus callosum. By contrast, there were no relationships between ELS and volumetric analysis of the CC regions. The two groups did not differ significantly on measures of current depression, stress or anxiety.Conclusion: Our results reveal that greater exposure to ELS is associated with microstructural alterations in the white matter in the absence of significant volumetric changes. Importantly, our results indicate that exposure to ELS is associated with abnormalities on DTI despite the absence of clinically significant psychiatric symptoms. Future studies are needed to determine whether specific types of ELS are more likely to impact brain structure and function.
format	article
author	Robert Paul Lorrie Henry Stuart M Grieve Thomas J Guilmette Raymond Niaura et al
author_facet	Robert Paul Lorrie Henry Stuart M Grieve Thomas J Guilmette Raymond Niaura et al
author_sort	Robert Paul
title	The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population
title_short	The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population
title_full	The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population
title_fullStr	The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population
title_full_unstemmed	The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population
title_sort	relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/78a08fa529a247da81ef5c38658d86e5
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The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population

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