Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin

Genetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (<i>FTO</i>) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber inta...

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Autores principales:	Przemyslaw Czajkowski, Edyta Adamska-Patruno, Witold Bauer, Urszula Krasowska, Joanna Fiedorczuk, Monika Moroz, Maria Gorska, Adam Kretowski
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>FTO</i> gene dietary fiber gene–diet interaction glucose metabolism macronutrients obesity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/78a1d2efafa4476fb8cc61f7f4d56a60
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spelling	oai:doaj.org-article:78a1d2efafa4476fb8cc61f7f4d56a602021-11-25T16:28:41ZDietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin10.3390/antiox101117932076-3921https://doaj.org/article/78a1d2efafa4476fb8cc61f7f4d56a602021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1793https://doaj.org/toc/2076-3921Genetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (<i>FTO</i>) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber intake on the obesity-related parameters and lipid profile in the Polish population. We selected 819 Polish Caucasian adult subjects (52.5% female and 47.5% male) for a final gene–diet interaction analysis, with mean BMI 28.5 (±6.6) kg/m<sup>2</sup>. We performed measurements of anthropometric parameters, total body fat content and distribution, and blood glucose, insulin, and lipid concentrations. Daily fiber intake was analyzed based on 3-day food-intake diaries, and daily physical activity was evaluated based on the International Physical Activity Questionnaire—Long Form. Our study shows that carriers of the GG genotype (rs3751812), CC genotype (rs8050136), and GG genotype (rs6499640) presented lower hip circumference if daily fiber intake was above 18 g per day. Additionally, GG genotype (rs3751812) and CC genotype (rs8050136) carriers showed surprisingly higher total cholesterol and LDL-cholesterol levels when they were stratified to the group with higher than median fiber intake. The results of this study highlight that high-fiber diets may positively affect anthropometric parameters but may also worsen lipid profile dependent on the <i>FTO</i> genotype.Przemyslaw CzajkowskiEdyta Adamska-PatrunoWitold BauerUrszula KrasowskaJoanna FiedorczukMonika MorozMaria GorskaAdam KretowskiMDPI AGarticle<i>FTO</i> genedietary fibergene–diet interactionglucose metabolismmacronutrientsobesityTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1793, p 1793 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>FTO</i> gene dietary fiber gene–diet interaction glucose metabolism macronutrients obesity Therapeutics. Pharmacology RM1-950
spellingShingle	<i>FTO</i> gene dietary fiber gene–diet interaction glucose metabolism macronutrients obesity Therapeutics. Pharmacology RM1-950 Przemyslaw Czajkowski Edyta Adamska-Patruno Witold Bauer Urszula Krasowska Joanna Fiedorczuk Monika Moroz Maria Gorska Adam Kretowski Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
description	Genetic and environmental factors play a key role in the development of obesity. The aim of this study was to explore the potential effect of fat mass and obesity-associated (<i>FTO</i>) rs3751812, rs8050136, rs9939609, rs6499640, rs8044769, and rs7190492 genotypes and dietary fiber intake on the obesity-related parameters and lipid profile in the Polish population. We selected 819 Polish Caucasian adult subjects (52.5% female and 47.5% male) for a final gene–diet interaction analysis, with mean BMI 28.5 (±6.6) kg/m<sup>2</sup>. We performed measurements of anthropometric parameters, total body fat content and distribution, and blood glucose, insulin, and lipid concentrations. Daily fiber intake was analyzed based on 3-day food-intake diaries, and daily physical activity was evaluated based on the International Physical Activity Questionnaire—Long Form. Our study shows that carriers of the GG genotype (rs3751812), CC genotype (rs8050136), and GG genotype (rs6499640) presented lower hip circumference if daily fiber intake was above 18 g per day. Additionally, GG genotype (rs3751812) and CC genotype (rs8050136) carriers showed surprisingly higher total cholesterol and LDL-cholesterol levels when they were stratified to the group with higher than median fiber intake. The results of this study highlight that high-fiber diets may positively affect anthropometric parameters but may also worsen lipid profile dependent on the <i>FTO</i> genotype.
format	article
author	Przemyslaw Czajkowski Edyta Adamska-Patruno Witold Bauer Urszula Krasowska Joanna Fiedorczuk Monika Moroz Maria Gorska Adam Kretowski
author_facet	Przemyslaw Czajkowski Edyta Adamska-Patruno Witold Bauer Urszula Krasowska Joanna Fiedorczuk Monika Moroz Maria Gorska Adam Kretowski
author_sort	Przemyslaw Czajkowski
title	Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
title_short	Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
title_full	Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
title_fullStr	Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
title_full_unstemmed	Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin
title_sort	dietary fiber intake may influence the impact of <i>fto</i> genetic variants on obesity parameters and lipid profile—a cohort study of a caucasian population of polish origin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/78a1d2efafa4476fb8cc61f7f4d56a60
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Dietary Fiber Intake May Influence the Impact of <i>FTO</i> Genetic Variants on Obesity Parameters and Lipid Profile—A Cohort Study of a Caucasian Population of Polish Origin

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