Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.

The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure. Midline glial cells are known to play a role in CC d...

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Autores principales:	Mathieu Niquille, Sonia Garel, Fanny Mann, Jean-Pierre Hornung, Belkacem Otsmane, Sébastien Chevalley, Carlos Parras, Francois Guillemot, Patricia Gaspar, Yuchio Yanagawa, Cécile Lebrand
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/78a82df9ab1543d3ac8e92d5344194e0
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spelling	oai:doaj.org-article:78a82df9ab1543d3ac8e92d5344194e02021-11-25T05:34:30ZTransient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.1544-91731545-788510.1371/journal.pbio.1000230https://doaj.org/article/78a82df9ab1543d3ac8e92d5344194e02009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19859539/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure. Midline glial cells are known to play a role in CC development, but we here show that two transient populations of midline neurons also make major contributions to the formation of this commissure. We report that these two neuronal populations enter the CC midline prior to the arrival of callosal pioneer axons. Using a combination of mutant analysis and in vitro assays, we demonstrate that CC neurons are necessary for normal callosal axon navigation. They exert an attractive influence on callosal axons, in part via Semaphorin 3C and its receptor Neuropilin-1. By revealing a novel and essential role for these neuronal populations in the pathfinding of a major cerebral commissure, our study brings new perspectives to pathophysiological mechanisms altering CC formation.Mathieu NiquilleSonia GarelFanny MannJean-Pierre HornungBelkacem OtsmaneSébastien ChevalleyCarlos ParrasFrancois GuillemotPatricia GasparYuchio YanagawaCécile LebrandPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 10, p e1000230 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mathieu Niquille Sonia Garel Fanny Mann Jean-Pierre Hornung Belkacem Otsmane Sébastien Chevalley Carlos Parras Francois Guillemot Patricia Gaspar Yuchio Yanagawa Cécile Lebrand Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
description	The corpus callosum (CC) is the main pathway responsible for interhemispheric communication. CC agenesis is associated with numerous human pathologies, suggesting that a range of developmental defects can result in abnormalities in this structure. Midline glial cells are known to play a role in CC development, but we here show that two transient populations of midline neurons also make major contributions to the formation of this commissure. We report that these two neuronal populations enter the CC midline prior to the arrival of callosal pioneer axons. Using a combination of mutant analysis and in vitro assays, we demonstrate that CC neurons are necessary for normal callosal axon navigation. They exert an attractive influence on callosal axons, in part via Semaphorin 3C and its receptor Neuropilin-1. By revealing a novel and essential role for these neuronal populations in the pathfinding of a major cerebral commissure, our study brings new perspectives to pathophysiological mechanisms altering CC formation.
format	article
author	Mathieu Niquille Sonia Garel Fanny Mann Jean-Pierre Hornung Belkacem Otsmane Sébastien Chevalley Carlos Parras Francois Guillemot Patricia Gaspar Yuchio Yanagawa Cécile Lebrand
author_facet	Mathieu Niquille Sonia Garel Fanny Mann Jean-Pierre Hornung Belkacem Otsmane Sébastien Chevalley Carlos Parras Francois Guillemot Patricia Gaspar Yuchio Yanagawa Cécile Lebrand
author_sort	Mathieu Niquille
title	Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
title_short	Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
title_full	Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
title_fullStr	Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
title_full_unstemmed	Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
title_sort	transient neuronal populations are required to guide callosal axons: a role for semaphorin 3c.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/78a82df9ab1543d3ac8e92d5344194e0
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Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.

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