Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma

Objective: To investigate the correlation between the clinicopathological features and prognosis in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTCL). Methods: One hundred and four patients diagnosed with ENKTCL at the Department of Pathology, Cancer Hospital, Chinese Academy of...

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Autores principales:	Lin-Shu Zeng, Wen-Ting Huang, Tian Qiu, Ling Shan, Lei Guo, Jian-Ming Ying, Ning Lyu, Xiao-Li Feng
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2017
Materias:	Extranodal natural killer/T-cell lymphoma Pathology Immunohistochemistry Prognosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/78b00d59330a4b4e889c8d6f54c70ff3
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spelling	oai:doaj.org-article:78b00d59330a4b4e889c8d6f54c70ff32021-12-02T14:14:58ZCorrelation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma2095-882X10.1016/j.cdtm.2017.11.003https://doaj.org/article/78b00d59330a4b4e889c8d6f54c70ff32017-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X17300750https://doaj.org/toc/2095-882XObjective: To investigate the correlation between the clinicopathological features and prognosis in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTCL). Methods: One hundred and four patients diagnosed with ENKTCL at the Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China from November 1991 to September 2011 were included in the study. The clinicopathological features and their correlations with disease prognosis were evaluated in these patients. Results: The number of effective follow-up cases was 56 (53.8%) by the end of last follow-up in October 2015. Univariate survival analysis showed that granzyme B, perforin, and Bcl-2 expression was significantly associated with a poor prognosis in ENKTCL (P = 0.033, 0.004, and 0.034, respectively), whereas platelet-derived growth factor receptor-alpha (PDGFRA) expression was significantly associated with a better prognosis (P = 0.034). Ki-67 overexpression (≥50%) was significantly associated with a poor prognosis (P = 0.017). Different treatment approaches were also associated with prognosis (P = 0.014); specifically, the efficacies of combination treatments including chemotherapy and radiotherapy, and autologous hematopoietic stem cell transplantation were significantly better than those involving radiotherapy and chemotherapy alone. Patient gender, age, tumor location, staging, the presence of B symptoms, pretreatment lactate dehydrogenase levels, and β2-microglobulin levels were not associated with the prognosis of ENKTCL (P > 0.05). However, multivariate analyses showed that the treatment approach and all the immune markers were not independent prognostic factors for ENKTCL. Conclusion: Granzyme B, perforin, and Bcl-2 expression and Ki-67 overexpression (≥50%) might be adverse prognostic factors for ENKTCL, whereas PDGFRA-positivity suggested a better disease prognosis. In addition, different treatment approaches might be closely related to patient prognosis.Lin-Shu ZengWen-Ting HuangTian QiuLing ShanLei GuoJian-Ming YingNing LyuXiao-Li FengKeAi Communications Co., Ltd.articleExtranodal natural killer/T-cell lymphomaPathologyImmunohistochemistryPrognosisMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 4, Pp 252-259 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Extranodal natural killer/T-cell lymphoma Pathology Immunohistochemistry Prognosis Medicine (General) R5-920
spellingShingle	Extranodal natural killer/T-cell lymphoma Pathology Immunohistochemistry Prognosis Medicine (General) R5-920 Lin-Shu Zeng Wen-Ting Huang Tian Qiu Ling Shan Lei Guo Jian-Ming Ying Ning Lyu Xiao-Li Feng Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma
description	Objective: To investigate the correlation between the clinicopathological features and prognosis in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTCL). Methods: One hundred and four patients diagnosed with ENKTCL at the Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China from November 1991 to September 2011 were included in the study. The clinicopathological features and their correlations with disease prognosis were evaluated in these patients. Results: The number of effective follow-up cases was 56 (53.8%) by the end of last follow-up in October 2015. Univariate survival analysis showed that granzyme B, perforin, and Bcl-2 expression was significantly associated with a poor prognosis in ENKTCL (P = 0.033, 0.004, and 0.034, respectively), whereas platelet-derived growth factor receptor-alpha (PDGFRA) expression was significantly associated with a better prognosis (P = 0.034). Ki-67 overexpression (≥50%) was significantly associated with a poor prognosis (P = 0.017). Different treatment approaches were also associated with prognosis (P = 0.014); specifically, the efficacies of combination treatments including chemotherapy and radiotherapy, and autologous hematopoietic stem cell transplantation were significantly better than those involving radiotherapy and chemotherapy alone. Patient gender, age, tumor location, staging, the presence of B symptoms, pretreatment lactate dehydrogenase levels, and β2-microglobulin levels were not associated with the prognosis of ENKTCL (P > 0.05). However, multivariate analyses showed that the treatment approach and all the immune markers were not independent prognostic factors for ENKTCL. Conclusion: Granzyme B, perforin, and Bcl-2 expression and Ki-67 overexpression (≥50%) might be adverse prognostic factors for ENKTCL, whereas PDGFRA-positivity suggested a better disease prognosis. In addition, different treatment approaches might be closely related to patient prognosis.
format	article
author	Lin-Shu Zeng Wen-Ting Huang Tian Qiu Ling Shan Lei Guo Jian-Ming Ying Ning Lyu Xiao-Li Feng
author_facet	Lin-Shu Zeng Wen-Ting Huang Tian Qiu Ling Shan Lei Guo Jian-Ming Ying Ning Lyu Xiao-Li Feng
author_sort	Lin-Shu Zeng
title	Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma
title_short	Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma
title_full	Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma
title_fullStr	Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma
title_full_unstemmed	Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma
title_sort	correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/t cell lymphoma
publisher	KeAi Communications Co., Ltd.
publishDate	2017
url	https://doaj.org/article/78b00d59330a4b4e889c8d6f54c70ff3
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Correlation between the clinicopathological features and prognosis in patients with extranodal natural killer/T cell lymphoma

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