Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B
ABSTRACT Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of the breast, head/neck, cervix, bladder, lung, ovary, and other tissues. A3B is u...
Guardado en:
Autores principales: | Valdimara C. Vieira, Brandon Leonard, Elizabeth A. White, Gabriel J. Starrett, Nuri A. Temiz, Laurel D. Lorenz, Denis Lee, Marcelo A. Soares, Paul F. Lambert, Peter M. Howley, Reuben S. Harris |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/78b02926d2814d79a2e5419970d5363e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
por: Gabriel J. Starrett, et al.
Publicado: (2016) -
Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase.
por: Iñigo Narvaiza, et al.
Publicado: (2009) -
Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G
por: Michael Morse, et al.
Publicado: (2017) -
AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates
por: Mei-Chen Liu, et al.
Publicado: (2018) -
Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus
por: Danielle Perez-Bercoff, et al.
Publicado: (2021)