The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Mechanisms underlying increasing artemisinin resistance of Plasmodium in Southeast Asia remain unclear. Here, Zhu et al. integrate TWAS, GWAS and eQTL analyses for 773 P. falciparum isolates and identify genetic and transcriptomic backgrounds to artemisinin resistance.

Guardado en:

Detalles Bibliográficos
Autores principales:	Lei Zhu, Jaishree Tripathi, Frances Maureen Rocamora, Olivo Miotto, Rob van der Pluijm, Till S. Voss, Sachel Mok, Dominic P. Kwiatkowski, François Nosten, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech, Tracking Resistance to Artemisinin Collaboration I
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78b188f3f3594bb18931bf64b446c61b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:78b188f3f3594bb18931bf64b446c61b
record_format	dspace
spelling	oai:doaj.org-article:78b188f3f3594bb18931bf64b446c61b2021-12-02T15:34:47ZThe origins of malaria artemisinin resistance defined by a genetic and transcriptomic background10.1038/s41467-018-07588-x2041-1723https://doaj.org/article/78b188f3f3594bb18931bf64b446c61b2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07588-xhttps://doaj.org/toc/2041-1723Mechanisms underlying increasing artemisinin resistance of Plasmodium in Southeast Asia remain unclear. Here, Zhu et al. integrate TWAS, GWAS and eQTL analyses for 773 P. falciparum isolates and identify genetic and transcriptomic backgrounds to artemisinin resistance.Lei ZhuJaishree TripathiFrances Maureen RocamoraOlivo MiottoRob van der PluijmTill S. VossSachel MokDominic P. KwiatkowskiFrançois NostenNicholas P. J. DayNicholas J. WhiteArjen M. DondorpZbynek BozdechTracking Resistance to Artemisinin Collaboration INature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Zhu Jaishree Tripathi Frances Maureen Rocamora Olivo Miotto Rob van der Pluijm Till S. Voss Sachel Mok Dominic P. Kwiatkowski François Nosten Nicholas P. J. Day Nicholas J. White Arjen M. Dondorp Zbynek Bozdech Tracking Resistance to Artemisinin Collaboration I The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
description	Mechanisms underlying increasing artemisinin resistance of Plasmodium in Southeast Asia remain unclear. Here, Zhu et al. integrate TWAS, GWAS and eQTL analyses for 773 P. falciparum isolates and identify genetic and transcriptomic backgrounds to artemisinin resistance.
format	article
author	Lei Zhu Jaishree Tripathi Frances Maureen Rocamora Olivo Miotto Rob van der Pluijm Till S. Voss Sachel Mok Dominic P. Kwiatkowski François Nosten Nicholas P. J. Day Nicholas J. White Arjen M. Dondorp Zbynek Bozdech Tracking Resistance to Artemisinin Collaboration I
author_facet	Lei Zhu Jaishree Tripathi Frances Maureen Rocamora Olivo Miotto Rob van der Pluijm Till S. Voss Sachel Mok Dominic P. Kwiatkowski François Nosten Nicholas P. J. Day Nicholas J. White Arjen M. Dondorp Zbynek Bozdech Tracking Resistance to Artemisinin Collaboration I
author_sort	Lei Zhu
title	The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
title_short	The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
title_full	The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
title_fullStr	The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
title_full_unstemmed	The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
title_sort	origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/78b188f3f3594bb18931bf64b446c61b
work_keys_str_mv	AT leizhu theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT jaishreetripathi theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT francesmaureenrocamora theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT olivomiotto theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT robvanderpluijm theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT tillsvoss theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT sachelmok theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT dominicpkwiatkowski theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT francoisnosten theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT nicholaspjday theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT nicholasjwhite theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT arjenmdondorp theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT zbynekbozdech theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT trackingresistancetoartemisinincollaborationi theoriginsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT leizhu originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT jaishreetripathi originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT francesmaureenrocamora originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT olivomiotto originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT robvanderpluijm originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT tillsvoss originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT sachelmok originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT dominicpkwiatkowski originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT francoisnosten originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT nicholaspjday originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT nicholasjwhite originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT arjenmdondorp originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT zbynekbozdech originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground AT trackingresistancetoartemisinincollaborationi originsofmalariaartemisininresistancedefinedbyageneticandtranscriptomicbackground
_version_	1718386726796263424

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Ejemplares similares