Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients

Objective: This study aimed to: (1) evaluate the association between myocardial fibrosis (MF) quantified by extracellular volume fraction (ECV) and myocardial strain measured by two-dimensional (2D)- and three-dimensional speckle-tracking echocardiography (3D-STE) and (2) further investigate which s...

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Autores principales:	Wei Sun, Xuehua Shen, Jing Wang, Shuangshuang Zhu, Yanting Zhang, Chun Wu, Yuji Xie, Yun Yang, Nianguo Dong, Guohua Wang, Yuman Li, Qing Lv, Bo Liang, Li Zhang, Mingxing Xie
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	heart transplant diffuse myocardial fibrosis cardiovascular magnetic resonance extracellular volume fraction speckle tracking echocardiography Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/78b18c283be1448bb287dbfd5c062f3f
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spelling	oai:doaj.org-article:78b18c283be1448bb287dbfd5c062f3f2021-12-01T16:01:22ZAssociation Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients2297-055X10.3389/fcvm.2021.727745https://doaj.org/article/78b18c283be1448bb287dbfd5c062f3f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.727745/fullhttps://doaj.org/toc/2297-055XObjective: This study aimed to: (1) evaluate the association between myocardial fibrosis (MF) quantified by extracellular volume fraction (ECV) and myocardial strain measured by two-dimensional (2D)- and three-dimensional speckle-tracking echocardiography (3D-STE) and (2) further investigate which strain parameter measured by 2D- and 3D-STE is the more robust predictor of MF in heart transplant (HT) recipients.Methods: A total of 40 patients with HT and 20 healthy controls were prospectively enrolled. Left ventricular (LV)-global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were measured by 2D- and 3D-STE. LV diffuse MF was defined by cardiovascular magnetic resonance (CMR)-ECV.Results: The HT recipients had a significantly higher native T1 and ECV than healthy controls (1043.8 ± 34.0 vs. 999.7 ± 19.7 ms, p < 0.001; 26.6 ± 2.7 vs. 24.3 ± 1.8%, p = 0.02). The 3D- and 2D-STE-LVGLS and LVGCS were lower (p < 0.005) in the HT recipients than in healthy controls. ECV showed a moderate correlation with 2D-LVGLS (r = 0.53, p = 0.002) and 3D-LVGLS (r = 0.60, p < 0.001), but it was not correlated with 2D or 3D-LVGCS, or LVGRS. Furthermore, 3D-LVGLS and 2D-LVGLS had a similar correlation with CMR-ECV (r = 0.60 vs. 0.53, p = 0.670). A separate stepwise multivariate linear analysis showed that both the 2D-LVGLS (β = 0.39, p = 0.019) and 3D-LVGLS (β = 0.54, p < 0.001) were independently associated with CMR-ECV.Conclusion: CMR marker of diffuse MF was present in asymptomatic patients with HT and appeared to be associated with decreased myocardial strain by echocardiography. Both the 2D- and 3D-LVGLS were independently correlated with diffuse LVMF, which may provide an alternative non-invasive tool for monitoring the development of adverse fibrotic remodeling during the follow-up of HT recipients.Wei SunWei SunWei SunXuehua ShenXuehua ShenJing WangShuangshuang ZhuShuangshuang ZhuShuangshuang ZhuYanting ZhangYanting ZhangYanting ZhangChun WuChun WuChun WuYuji XieYuji XieYuji XieYun YangYun YangYun YangNianguo DongGuohua WangYuman LiYuman LiYuman LiQing LvQing LvQing LvBo LiangLi ZhangLi ZhangLi ZhangMingxing XieMingxing XieMingxing XieFrontiers Media S.A.articleheart transplantdiffuse myocardial fibrosiscardiovascular magnetic resonanceextracellular volume fractionspeckle tracking echocardiographyDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart transplant diffuse myocardial fibrosis cardiovascular magnetic resonance extracellular volume fraction speckle tracking echocardiography Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	heart transplant diffuse myocardial fibrosis cardiovascular magnetic resonance extracellular volume fraction speckle tracking echocardiography Diseases of the circulatory (Cardiovascular) system RC666-701 Wei Sun Wei Sun Wei Sun Xuehua Shen Xuehua Shen Jing Wang Shuangshuang Zhu Shuangshuang Zhu Shuangshuang Zhu Yanting Zhang Yanting Zhang Yanting Zhang Chun Wu Chun Wu Chun Wu Yuji Xie Yuji Xie Yuji Xie Yun Yang Yun Yang Yun Yang Nianguo Dong Guohua Wang Yuman Li Yuman Li Yuman Li Qing Lv Qing Lv Qing Lv Bo Liang Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients
description	Objective: This study aimed to: (1) evaluate the association between myocardial fibrosis (MF) quantified by extracellular volume fraction (ECV) and myocardial strain measured by two-dimensional (2D)- and three-dimensional speckle-tracking echocardiography (3D-STE) and (2) further investigate which strain parameter measured by 2D- and 3D-STE is the more robust predictor of MF in heart transplant (HT) recipients.Methods: A total of 40 patients with HT and 20 healthy controls were prospectively enrolled. Left ventricular (LV)-global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were measured by 2D- and 3D-STE. LV diffuse MF was defined by cardiovascular magnetic resonance (CMR)-ECV.Results: The HT recipients had a significantly higher native T1 and ECV than healthy controls (1043.8 ± 34.0 vs. 999.7 ± 19.7 ms, p < 0.001; 26.6 ± 2.7 vs. 24.3 ± 1.8%, p = 0.02). The 3D- and 2D-STE-LVGLS and LVGCS were lower (p < 0.005) in the HT recipients than in healthy controls. ECV showed a moderate correlation with 2D-LVGLS (r = 0.53, p = 0.002) and 3D-LVGLS (r = 0.60, p < 0.001), but it was not correlated with 2D or 3D-LVGCS, or LVGRS. Furthermore, 3D-LVGLS and 2D-LVGLS had a similar correlation with CMR-ECV (r = 0.60 vs. 0.53, p = 0.670). A separate stepwise multivariate linear analysis showed that both the 2D-LVGLS (β = 0.39, p = 0.019) and 3D-LVGLS (β = 0.54, p < 0.001) were independently associated with CMR-ECV.Conclusion: CMR marker of diffuse MF was present in asymptomatic patients with HT and appeared to be associated with decreased myocardial strain by echocardiography. Both the 2D- and 3D-LVGLS were independently correlated with diffuse LVMF, which may provide an alternative non-invasive tool for monitoring the development of adverse fibrotic remodeling during the follow-up of HT recipients.
format	article
author	Wei Sun Wei Sun Wei Sun Xuehua Shen Xuehua Shen Jing Wang Shuangshuang Zhu Shuangshuang Zhu Shuangshuang Zhu Yanting Zhang Yanting Zhang Yanting Zhang Chun Wu Chun Wu Chun Wu Yuji Xie Yuji Xie Yuji Xie Yun Yang Yun Yang Yun Yang Nianguo Dong Guohua Wang Yuman Li Yuman Li Yuman Li Qing Lv Qing Lv Qing Lv Bo Liang Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie
author_facet	Wei Sun Wei Sun Wei Sun Xuehua Shen Xuehua Shen Jing Wang Shuangshuang Zhu Shuangshuang Zhu Shuangshuang Zhu Yanting Zhang Yanting Zhang Yanting Zhang Chun Wu Chun Wu Chun Wu Yuji Xie Yuji Xie Yuji Xie Yun Yang Yun Yang Yun Yang Nianguo Dong Guohua Wang Yuman Li Yuman Li Yuman Li Qing Lv Qing Lv Qing Lv Bo Liang Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie
author_sort	Wei Sun
title	Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients
title_short	Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients
title_full	Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients
title_fullStr	Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients
title_full_unstemmed	Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients
title_sort	association between 2d- and 3d-speckle-tracking longitudinal strain and cardiovascular magnetic resonance evidence of diffuse myocardial fibrosis in heart transplant recipients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/78b18c283be1448bb287dbfd5c062f3f
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Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients

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