Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis

The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal s...

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Autores principales:	Jonathan Dorival, Fanny Risser, Christophe Jacob, Sabrina Collin, Gerald Dräger, Cédric Paris, Benjamin Chagot, Andreas Kirschning, Arnaud Gruez, Kira J. Weissman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78b38c0a3e20488982c5b94105e162f4
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spelling	oai:doaj.org-article:78b38c0a3e20488982c5b94105e162f42021-12-02T17:32:19ZInsights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis10.1038/s41467-018-06323-w2041-1723https://doaj.org/article/78b38c0a3e20488982c5b94105e162f42018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06323-whttps://doaj.org/toc/2041-1723The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal structures, which explains the unusual dual activity of LkcE.Jonathan DorivalFanny RisserChristophe JacobSabrina CollinGerald DrägerCédric ParisBenjamin ChagotAndreas KirschningArnaud GruezKira J. WeissmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonathan Dorival Fanny Risser Christophe Jacob Sabrina Collin Gerald Dräger Cédric Paris Benjamin Chagot Andreas Kirschning Arnaud Gruez Kira J. Weissman Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
description	The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal structures, which explains the unusual dual activity of LkcE.
format	article
author	Jonathan Dorival Fanny Risser Christophe Jacob Sabrina Collin Gerald Dräger Cédric Paris Benjamin Chagot Andreas Kirschning Arnaud Gruez Kira J. Weissman
author_facet	Jonathan Dorival Fanny Risser Christophe Jacob Sabrina Collin Gerald Dräger Cédric Paris Benjamin Chagot Andreas Kirschning Arnaud Gruez Kira J. Weissman
author_sort	Jonathan Dorival
title	Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
title_short	Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
title_full	Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
title_fullStr	Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
title_full_unstemmed	Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
title_sort	insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/78b38c0a3e20488982c5b94105e162f4
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Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis

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