Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells

Oxidative stress caused by the production of reactive oxygen species (ROS) plays a major role in inflammatory processes. We hypothesized that modulation of ROS via quercetin may protect against oxidative stress and inflammation. Thus, this study aimed to investigate the effects of quercetin on oxida...

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Autores principales:	Ok-Joo Sul, Seung Won Ra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxidative stress inflammation quercetin NADPH oxidases reactive oxygen species Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/78b8a9551b2a459f865b6b770be9fc9e
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spelling	oai:doaj.org-article:78b8a9551b2a459f865b6b770be9fc9e2021-11-25T18:28:39ZQuercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells10.3390/molecules262269491420-3049https://doaj.org/article/78b8a9551b2a459f865b6b770be9fc9e2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6949https://doaj.org/toc/1420-3049Oxidative stress caused by the production of reactive oxygen species (ROS) plays a major role in inflammatory processes. We hypothesized that modulation of ROS via quercetin may protect against oxidative stress and inflammation. Thus, this study aimed to investigate the effects of quercetin on oxidative stress and inflammation in lung epithelial A549 cells. The lipopolysaccharide (LPS)-induced elevation of intracellular ROS levels was reduced after quercetin treatment, which also almost completely abolished the mRNA and protein expression of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) induced by LPS stimulation. In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-κB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure. Our data demonstrated that quercetin decreased ROS-induced oxidative stress and inflammation by suppressing NOX2 production.Ok-Joo SulSeung Won RaMDPI AGarticleoxidative stressinflammationquercetinNADPH oxidasesreactive oxygen speciesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6949, p 6949 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress inflammation quercetin NADPH oxidases reactive oxygen species Organic chemistry QD241-441
spellingShingle	oxidative stress inflammation quercetin NADPH oxidases reactive oxygen species Organic chemistry QD241-441 Ok-Joo Sul Seung Won Ra Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells
description	Oxidative stress caused by the production of reactive oxygen species (ROS) plays a major role in inflammatory processes. We hypothesized that modulation of ROS via quercetin may protect against oxidative stress and inflammation. Thus, this study aimed to investigate the effects of quercetin on oxidative stress and inflammation in lung epithelial A549 cells. The lipopolysaccharide (LPS)-induced elevation of intracellular ROS levels was reduced after quercetin treatment, which also almost completely abolished the mRNA and protein expression of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) induced by LPS stimulation. In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-κB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure. Our data demonstrated that quercetin decreased ROS-induced oxidative stress and inflammation by suppressing NOX2 production.
format	article
author	Ok-Joo Sul Seung Won Ra
author_facet	Ok-Joo Sul Seung Won Ra
author_sort	Ok-Joo Sul
title	Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells
title_short	Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells
title_full	Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells
title_fullStr	Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells
title_full_unstemmed	Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells
title_sort	quercetin prevents lps-induced oxidative stress and inflammation by modulating nox2/ros/nf-kb in lung epithelial cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/78b8a9551b2a459f865b6b770be9fc9e
work_keys_str_mv	AT okjoosul quercetinpreventslpsinducedoxidativestressandinflammationbymodulatingnox2rosnfkbinlungepithelialcells AT seungwonra quercetinpreventslpsinducedoxidativestressandinflammationbymodulatingnox2rosnfkbinlungepithelialcells
_version_	1718411083735105536

Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells

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