Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

ABSTRACT: Hawthorn-leaves flavonoids (HF), extracted from hawthorn leaves, were reported to exert antioxidant, anti-inflammatory and hypolipidemic properties. The aim of our study was to investigate the effects of dietary HF on the reproduction performance and liver lipid metabolism of aged breeder...

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Autores principales:	Hongjian Dai, Zengpeng Lv, Zhenwu Huang, Nanwei Ye, Simeng Li, Jingle Jiang, Ying Cheng, Fangxiong Shi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	hawthorn leaves flavonoids reproduction performance lipid metabolism antioxidant Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/78bb814ea7f04d9982074e88928a89ab
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spelling	oai:doaj.org-article:78bb814ea7f04d9982074e88928a89ab2021-11-24T04:22:38ZDietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens0032-579110.1016/j.psj.2021.101499https://doaj.org/article/78bb814ea7f04d9982074e88928a89ab2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0032579121005216https://doaj.org/toc/0032-5791ABSTRACT: Hawthorn-leaves flavonoids (HF), extracted from hawthorn leaves, were reported to exert antioxidant, anti-inflammatory and hypolipidemic properties. The aim of our study was to investigate the effects of dietary HF on the reproduction performance and liver lipid metabolism of aged breeder hens. A total of 270 aged Qiling breeder hens (60-wk-old) were randomly divided into 3 treatments: 1) basic corn-soybean diet (CON); 2) basic corn-soybean diet supplemented with 30 mg/kg HF (LHF); 3) basic corn-soybean diet supplemented with 60 mg/kg HF (HHF). The results showed that supplemented HF significantly improved the egg-laying rate and hatching rate of aged breeder hens (P < 0.05). HF treatment reduced the serum TG, T-CHO and L-LDL levels (P < 0.05), and upregulated the mRNA expressions of ESR1, ESR2, VTGⅡ, ApoB, and ApoVI in the liver (P < 0.05). Serum estrogen levels in HF treated groups were elevated compared with the CON group (P < 0.05). In the HHF group, the number of the primordial follicles was higher in comparison with the CON group (P < 0.05). Furthermore, dietary supplementation with HF improved the activity of antioxidant enzymes (T-AOC, GSH-Pχ) (P < 0.05), following with the reversed ovarian apoptosis and morphological damage. In addition, 60 mg/kg dietary HF upregulated the protein expression of PCNA and Nrf2 in the ovary (P < 0.05). In summary, dietary supplementation with HF could improve the reproduction performance through regulating liver lipid metabolism and improving ovarian function in aged breeder hens.Hongjian DaiZengpeng LvZhenwu HuangNanwei YeSimeng LiJingle JiangYing ChengFangxiong ShiElsevierarticlehawthorn leaves flavonoidsreproduction performancelipid metabolismantioxidantAnimal cultureSF1-1100ENPoultry Science, Vol 100, Iss 12, Pp 101499- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hawthorn leaves flavonoids reproduction performance lipid metabolism antioxidant Animal culture SF1-1100
spellingShingle	hawthorn leaves flavonoids reproduction performance lipid metabolism antioxidant Animal culture SF1-1100 Hongjian Dai Zengpeng Lv Zhenwu Huang Nanwei Ye Simeng Li Jingle Jiang Ying Cheng Fangxiong Shi Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
description	ABSTRACT: Hawthorn-leaves flavonoids (HF), extracted from hawthorn leaves, were reported to exert antioxidant, anti-inflammatory and hypolipidemic properties. The aim of our study was to investigate the effects of dietary HF on the reproduction performance and liver lipid metabolism of aged breeder hens. A total of 270 aged Qiling breeder hens (60-wk-old) were randomly divided into 3 treatments: 1) basic corn-soybean diet (CON); 2) basic corn-soybean diet supplemented with 30 mg/kg HF (LHF); 3) basic corn-soybean diet supplemented with 60 mg/kg HF (HHF). The results showed that supplemented HF significantly improved the egg-laying rate and hatching rate of aged breeder hens (P < 0.05). HF treatment reduced the serum TG, T-CHO and L-LDL levels (P < 0.05), and upregulated the mRNA expressions of ESR1, ESR2, VTGⅡ, ApoB, and ApoVI in the liver (P < 0.05). Serum estrogen levels in HF treated groups were elevated compared with the CON group (P < 0.05). In the HHF group, the number of the primordial follicles was higher in comparison with the CON group (P < 0.05). Furthermore, dietary supplementation with HF improved the activity of antioxidant enzymes (T-AOC, GSH-Pχ) (P < 0.05), following with the reversed ovarian apoptosis and morphological damage. In addition, 60 mg/kg dietary HF upregulated the protein expression of PCNA and Nrf2 in the ovary (P < 0.05). In summary, dietary supplementation with HF could improve the reproduction performance through regulating liver lipid metabolism and improving ovarian function in aged breeder hens.
format	article
author	Hongjian Dai Zengpeng Lv Zhenwu Huang Nanwei Ye Simeng Li Jingle Jiang Ying Cheng Fangxiong Shi
author_facet	Hongjian Dai Zengpeng Lv Zhenwu Huang Nanwei Ye Simeng Li Jingle Jiang Ying Cheng Fangxiong Shi
author_sort	Hongjian Dai
title	Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
title_short	Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
title_full	Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
title_fullStr	Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
title_full_unstemmed	Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
title_sort	dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/78bb814ea7f04d9982074e88928a89ab
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Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

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