α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance

Abstract Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart d...

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Autores principales:	Tian Zhang, Qiang Zheng, Yike Fu, Congkun Xie, Gonglin Fan, Yifan Wang, Yongjun Wu, Xiujun Cai, Gaorong Han, Xiang Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Heterostructure Sonodynamic therapy Self-supplied oxygen Tumor theranostic Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/78bbbef04bd04365a7bea062fb85818b
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spelling	oai:doaj.org-article:78bbbef04bd04365a7bea062fb85818b2021-11-08T11:01:26Zα-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance10.1186/s12951-021-01105-x1477-3155https://doaj.org/article/78bbbef04bd04365a7bea062fb85818b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01105-xhttps://doaj.org/toc/1477-3155Abstract Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent with ingenious bandgap and structural design. The Schottky barrier, due to its unique heterostructure, suppresses the recombination of sono-induced electrons and holes, enabling superior ROS generation. More importantly, the composite nanoparticles may effectively trigger a reoxygenation phenomenon to supply sufficient content of oxygen, favoring the ROS induction under the hypoxic condition and its extra role played for ultrasound imaging. In consequence, α-Fe2O3@Pt appears to enable effective tumor inhibition with imaging guidance, both in vitro and in vivo. This study has therefore demonstrated a highly potential platform for ultrasound-driven tumor theranostic, which may spark a series of further explorations in therapeutic systems with more rational material design. Graphical AbstractTian ZhangQiang ZhengYike FuCongkun XieGonglin FanYifan WangYongjun WuXiujun CaiGaorong HanXiang LiBMCarticleHeterostructureSonodynamic therapySelf-supplied oxygenTumor theranosticBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Heterostructure Sonodynamic therapy Self-supplied oxygen Tumor theranostic Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Heterostructure Sonodynamic therapy Self-supplied oxygen Tumor theranostic Biotechnology TP248.13-248.65 Medical technology R855-855.5 Tian Zhang Qiang Zheng Yike Fu Congkun Xie Gonglin Fan Yifan Wang Yongjun Wu Xiujun Cai Gaorong Han Xiang Li α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
description	Abstract Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent with ingenious bandgap and structural design. The Schottky barrier, due to its unique heterostructure, suppresses the recombination of sono-induced electrons and holes, enabling superior ROS generation. More importantly, the composite nanoparticles may effectively trigger a reoxygenation phenomenon to supply sufficient content of oxygen, favoring the ROS induction under the hypoxic condition and its extra role played for ultrasound imaging. In consequence, α-Fe2O3@Pt appears to enable effective tumor inhibition with imaging guidance, both in vitro and in vivo. This study has therefore demonstrated a highly potential platform for ultrasound-driven tumor theranostic, which may spark a series of further explorations in therapeutic systems with more rational material design. Graphical Abstract
format	article
author	Tian Zhang Qiang Zheng Yike Fu Congkun Xie Gonglin Fan Yifan Wang Yongjun Wu Xiujun Cai Gaorong Han Xiang Li
author_facet	Tian Zhang Qiang Zheng Yike Fu Congkun Xie Gonglin Fan Yifan Wang Yongjun Wu Xiujun Cai Gaorong Han Xiang Li
author_sort	Tian Zhang
title	α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
title_short	α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
title_full	α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
title_fullStr	α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
title_full_unstemmed	α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
title_sort	α-fe2o3@pt heterostructure particles to enable sonodynamic therapy with self-supplied o2 and imaging-guidance
publisher	BMC
publishDate	2021
url	https://doaj.org/article/78bbbef04bd04365a7bea062fb85818b
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α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance

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