Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Antigenic site B in influenza A virus hemagglutinin (HA) is immunodominant in circulating human H3N2 strains. Using deep mutational scanning, Wu et al. here define the local fitness landscapes of HA antigenic site B in six human H3N2 strains, providing insights into evolvability of influenza antigen...

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Autores principales:	Nicholas C. Wu, Jakub Otwinowski, Andrew J. Thompson, Corwin M. Nycholat, Armita Nourmohammad, Ian A. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78bbd94e04ac49b8926eabf56d6fbb17
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spelling	oai:doaj.org-article:78bbd94e04ac49b8926eabf56d6fbb172021-12-02T15:39:07ZMajor antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape10.1038/s41467-020-15102-52041-1723https://doaj.org/article/78bbd94e04ac49b8926eabf56d6fbb172020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15102-5https://doaj.org/toc/2041-1723Antigenic site B in influenza A virus hemagglutinin (HA) is immunodominant in circulating human H3N2 strains. Using deep mutational scanning, Wu et al. here define the local fitness landscapes of HA antigenic site B in six human H3N2 strains, providing insights into evolvability of influenza antigenicity.Nicholas C. WuJakub OtwinowskiAndrew J. ThompsonCorwin M. NycholatArmita NourmohammadIan A. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas C. Wu Jakub Otwinowski Andrew J. Thompson Corwin M. Nycholat Armita Nourmohammad Ian A. Wilson Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
description	Antigenic site B in influenza A virus hemagglutinin (HA) is immunodominant in circulating human H3N2 strains. Using deep mutational scanning, Wu et al. here define the local fitness landscapes of HA antigenic site B in six human H3N2 strains, providing insights into evolvability of influenza antigenicity.
format	article
author	Nicholas C. Wu Jakub Otwinowski Andrew J. Thompson Corwin M. Nycholat Armita Nourmohammad Ian A. Wilson
author_facet	Nicholas C. Wu Jakub Otwinowski Andrew J. Thompson Corwin M. Nycholat Armita Nourmohammad Ian A. Wilson
author_sort	Nicholas C. Wu
title	Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
title_short	Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
title_full	Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
title_fullStr	Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
title_full_unstemmed	Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
title_sort	major antigenic site b of human influenza h3n2 viruses has an evolving local fitness landscape
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/78bbd94e04ac49b8926eabf56d6fbb17
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Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

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