Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape
Antigenic site B in influenza A virus hemagglutinin (HA) is immunodominant in circulating human H3N2 strains. Using deep mutational scanning, Wu et al. here define the local fitness landscapes of HA antigenic site B in six human H3N2 strains, providing insights into evolvability of influenza antigen...
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Main Authors: | Nicholas C. Wu, Jakub Otwinowski, Andrew J. Thompson, Corwin M. Nycholat, Armita Nourmohammad, Ian A. Wilson |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
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Online Access: | https://doaj.org/article/78bbd94e04ac49b8926eabf56d6fbb17 |
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