Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

Antigenic site B in influenza A virus hemagglutinin (HA) is immunodominant in circulating human H3N2 strains. Using deep mutational scanning, Wu et al. here define the local fitness landscapes of HA antigenic site B in six human H3N2 strains, providing insights into evolvability of influenza antigen...

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Autores principales: Nicholas C. Wu, Jakub Otwinowski, Andrew J. Thompson, Corwin M. Nycholat, Armita Nourmohammad, Ian A. Wilson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/78bbd94e04ac49b8926eabf56d6fbb17
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