Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report

Background: Small bowel adenocarcinoma are relatively rare tumors of the digestive system. Due to the lack of specific screening methods, patients are often diagnosed at an advanced stage. At present, there is no specific surgical guidance and chemotherapy regimen for small bowel adenocarcinoma. Her...

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Autores principales:	Zhongyi Dong, Xiang Xia, Zizhen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	case reports intestinal cancers immune checkpoint inhibitor mesenteric vascular occlusion palliative care Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/78c1bfb62450484da203755dfd86c8a3
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spelling	oai:doaj.org-article:78c1bfb62450484da203755dfd86c8a32021-11-08T08:05:35ZSystemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report2296-858X10.3389/fmed.2021.764233https://doaj.org/article/78c1bfb62450484da203755dfd86c8a32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.764233/fullhttps://doaj.org/toc/2296-858XBackground: Small bowel adenocarcinoma are relatively rare tumors of the digestive system. Due to the lack of specific screening methods, patients are often diagnosed at an advanced stage. At present, there is no specific surgical guidance and chemotherapy regimen for small bowel adenocarcinoma. Here, we report a rare small bowel adenocarcinoma case with mesenteric vascular embolization and microsatellite instability, in which palliative surgery combined with chemotherapy and anti-Programmed cell death protein 1(PD-1) therapy resulted in complete remission.Case Presentation: The patient was a 55-year-old man who was admitted for suspected small bowel adenocarcinoma combined with incomplete ileus, mesenteric vascular occlusion and distant metastasis. We performed palliative surgery to remove adenocarcinoma as well as relieve obstruction. Then according to the pathological and immunohistochemical results (Stage IV and microsatellite instability), we used XELOX regimen combined with anti-PD-1 therapy. In last 2 years follow up, this patient achieved complete remission.Conclusions: The possibility of small intestinal tumor should be considered in patients with mesenteric vascular obstruction. PD-1 blockade is an effective therapy for small bowel adenocarcinoma with microsatellite instability.Zhongyi DongXiang XiaZizhen ZhangFrontiers Media S.A.articlecase reportsintestinal cancersimmune checkpoint inhibitormesenteric vascular occlusionpalliative careMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case reports intestinal cancers immune checkpoint inhibitor mesenteric vascular occlusion palliative care Medicine (General) R5-920
spellingShingle	case reports intestinal cancers immune checkpoint inhibitor mesenteric vascular occlusion palliative care Medicine (General) R5-920 Zhongyi Dong Xiang Xia Zizhen Zhang Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report
description	Background: Small bowel adenocarcinoma are relatively rare tumors of the digestive system. Due to the lack of specific screening methods, patients are often diagnosed at an advanced stage. At present, there is no specific surgical guidance and chemotherapy regimen for small bowel adenocarcinoma. Here, we report a rare small bowel adenocarcinoma case with mesenteric vascular embolization and microsatellite instability, in which palliative surgery combined with chemotherapy and anti-Programmed cell death protein 1(PD-1) therapy resulted in complete remission.Case Presentation: The patient was a 55-year-old man who was admitted for suspected small bowel adenocarcinoma combined with incomplete ileus, mesenteric vascular occlusion and distant metastasis. We performed palliative surgery to remove adenocarcinoma as well as relieve obstruction. Then according to the pathological and immunohistochemical results (Stage IV and microsatellite instability), we used XELOX regimen combined with anti-PD-1 therapy. In last 2 years follow up, this patient achieved complete remission.Conclusions: The possibility of small intestinal tumor should be considered in patients with mesenteric vascular obstruction. PD-1 blockade is an effective therapy for small bowel adenocarcinoma with microsatellite instability.
format	article
author	Zhongyi Dong Xiang Xia Zizhen Zhang
author_facet	Zhongyi Dong Xiang Xia Zizhen Zhang
author_sort	Zhongyi Dong
title	Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report
title_short	Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report
title_full	Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report
title_fullStr	Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report
title_full_unstemmed	Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report
title_sort	systemic therapy for microsatellite instability small bowel adenocarcinoma with mesenteric vascular embolism as initial symptom: a case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/78c1bfb62450484da203755dfd86c8a3
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_version_	1718442823259258880

Systemic Therapy for Microsatellite Instability Small Bowel Adenocarcinoma With Mesenteric Vascular Embolism as Initial Symptom: A Case Report

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