The m6A pathway facilitates sex determination in Drosophila

The m6A pathway facilitates sex determination in Drosophila

N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.

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Detalles Bibliográficos
Autores principales: Lijuan Kan, Anya V. Grozhik, Jeffrey Vedanayagam, Deepak P. Patil, Nan Pang, Kok-Seong Lim, Yi-Chun Huang, Brian Joseph, Ching-Jung Lin, Vladimir Despic, Jian Guo, Dong Yan, Shu Kondo, Wu-Min Deng, Peter C. Dedon, Samie R. Jaffrey, Eric C. Lai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/78c8d747fcf549a69021f4cf104fdd69
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Descripción
Sumario:N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.

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