The m6A pathway facilitates sex determination in Drosophila

N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.

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Autores principales:	Lijuan Kan, Anya V. Grozhik, Jeffrey Vedanayagam, Deepak P. Patil, Nan Pang, Kok-Seong Lim, Yi-Chun Huang, Brian Joseph, Ching-Jung Lin, Vladimir Despic, Jian Guo, Dong Yan, Shu Kondo, Wu-Min Deng, Peter C. Dedon, Samie R. Jaffrey, Eric C. Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78c8d747fcf549a69021f4cf104fdd69
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spelling	oai:doaj.org-article:78c8d747fcf549a69021f4cf104fdd692021-12-02T14:41:19ZThe m6A pathway facilitates sex determination in Drosophila10.1038/ncomms157372041-1723https://doaj.org/article/78c8d747fcf549a69021f4cf104fdd692017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15737https://doaj.org/toc/2041-1723N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.Lijuan KanAnya V. GrozhikJeffrey VedanayagamDeepak P. PatilNan PangKok-Seong LimYi-Chun HuangBrian JosephChing-Jung LinVladimir DespicJian GuoDong YanShu KondoWu-Min DengPeter C. DedonSamie R. JaffreyEric C. LaiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lijuan Kan Anya V. Grozhik Jeffrey Vedanayagam Deepak P. Patil Nan Pang Kok-Seong Lim Yi-Chun Huang Brian Joseph Ching-Jung Lin Vladimir Despic Jian Guo Dong Yan Shu Kondo Wu-Min Deng Peter C. Dedon Samie R. Jaffrey Eric C. Lai The m6A pathway facilitates sex determination in Drosophila
description	N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.
format	article
author	Lijuan Kan Anya V. Grozhik Jeffrey Vedanayagam Deepak P. Patil Nan Pang Kok-Seong Lim Yi-Chun Huang Brian Joseph Ching-Jung Lin Vladimir Despic Jian Guo Dong Yan Shu Kondo Wu-Min Deng Peter C. Dedon Samie R. Jaffrey Eric C. Lai
author_facet	Lijuan Kan Anya V. Grozhik Jeffrey Vedanayagam Deepak P. Patil Nan Pang Kok-Seong Lim Yi-Chun Huang Brian Joseph Ching-Jung Lin Vladimir Despic Jian Guo Dong Yan Shu Kondo Wu-Min Deng Peter C. Dedon Samie R. Jaffrey Eric C. Lai
author_sort	Lijuan Kan
title	The m6A pathway facilitates sex determination in Drosophila
title_short	The m6A pathway facilitates sex determination in Drosophila
title_full	The m6A pathway facilitates sex determination in Drosophila
title_fullStr	The m6A pathway facilitates sex determination in Drosophila
title_full_unstemmed	The m6A pathway facilitates sex determination in Drosophila
title_sort	m6a pathway facilitates sex determination in drosophila
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78c8d747fcf549a69021f4cf104fdd69
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The m6A pathway facilitates sex determination in Drosophila

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