Identification of genetic loci shared between schizophrenia and the Big Five personality traits

Abstract Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian s...

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Autores principales:	Olav B. Smeland, Yunpeng Wang, Min-Tzu Lo, Wen Li, Oleksandr Frei, Aree Witoelar, Martin Tesli, David A. Hinds, Joyce Y. Tung, Srdjan Djurovic, Chi-Hua Chen, Anders M. Dale, Ole A. Andreassen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78c98f40c1774248bc2eca70bc80f09b
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spelling	oai:doaj.org-article:78c98f40c1774248bc2eca70bc80f09b2021-12-02T16:07:59ZIdentification of genetic loci shared between schizophrenia and the Big Five personality traits10.1038/s41598-017-02346-32045-2322https://doaj.org/article/78c98f40c1774248bc2eca70bc80f09b2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02346-3https://doaj.org/toc/2045-2322Abstract Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.Olav B. SmelandYunpeng WangMin-Tzu LoWen LiOleksandr FreiAree WitoelarMartin TesliDavid A. HindsJoyce Y. TungSrdjan DjurovicChi-Hua ChenAnders M. DaleOle A. AndreassenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Olav B. Smeland Yunpeng Wang Min-Tzu Lo Wen Li Oleksandr Frei Aree Witoelar Martin Tesli David A. Hinds Joyce Y. Tung Srdjan Djurovic Chi-Hua Chen Anders M. Dale Ole A. Andreassen Identification of genetic loci shared between schizophrenia and the Big Five personality traits
description	Abstract Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium cohort (n = 82,315), we evaluated overlap in common genetic variants. The Big Five personality traits neuroticism, extraversion, openness, agreeableness and conscientiousness were measured using a web implementation of the Big Five Inventory. Applying the conditional false discovery rate approach, we increased discovery of genetic loci and identified two loci shared between neuroticism and schizophrenia and six loci shared between openness and schizophrenia. The study provides new insights into the relationship between personality traits and schizophrenia by highlighting genetic loci involved in their common genetic etiology.
format	article
author	Olav B. Smeland Yunpeng Wang Min-Tzu Lo Wen Li Oleksandr Frei Aree Witoelar Martin Tesli David A. Hinds Joyce Y. Tung Srdjan Djurovic Chi-Hua Chen Anders M. Dale Ole A. Andreassen
author_facet	Olav B. Smeland Yunpeng Wang Min-Tzu Lo Wen Li Oleksandr Frei Aree Witoelar Martin Tesli David A. Hinds Joyce Y. Tung Srdjan Djurovic Chi-Hua Chen Anders M. Dale Ole A. Andreassen
author_sort	Olav B. Smeland
title	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
title_short	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
title_full	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
title_fullStr	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
title_full_unstemmed	Identification of genetic loci shared between schizophrenia and the Big Five personality traits
title_sort	identification of genetic loci shared between schizophrenia and the big five personality traits
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78c98f40c1774248bc2eca70bc80f09b
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Identification of genetic loci shared between schizophrenia and the Big Five personality traits

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