A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

The origin of Fc receptor-based phagocytosis is unknown, although plasma lipid redistribution after solid structure binding induces similar phagocytic signaling. Here, Mu et al. show that PIP2 accumulation from plasma membrane deformation recruits Moesin to trigger receptor-independent phagocytosis.

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Autores principales: Libing Mu, Zhongyuan Tu, Lin Miao, Hefei Ruan, Ning Kang, Yongzhen Hei, Jiahuan Chen, Wei Wei, Fangling Gong, Bingjie Wang, Yanan Du, Guanghui Ma, Matthias W. Amerein, Tie Xia, Yan Shi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/78cb416c59cf49738095c6581a4fef6f
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spelling oai:doaj.org-article:78cb416c59cf49738095c6581a4fef6f2021-12-02T16:49:35ZA phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing10.1038/s41467-018-06744-72041-1723https://doaj.org/article/78cb416c59cf49738095c6581a4fef6f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06744-7https://doaj.org/toc/2041-1723The origin of Fc receptor-based phagocytosis is unknown, although plasma lipid redistribution after solid structure binding induces similar phagocytic signaling. Here, Mu et al. show that PIP2 accumulation from plasma membrane deformation recruits Moesin to trigger receptor-independent phagocytosis.Libing MuZhongyuan TuLin MiaoHefei RuanNing KangYongzhen HeiJiahuan ChenWei WeiFangling GongBingjie WangYanan DuGuanghui MaMatthias W. AmereinTie XiaYan ShiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Libing Mu
Zhongyuan Tu
Lin Miao
Hefei Ruan
Ning Kang
Yongzhen Hei
Jiahuan Chen
Wei Wei
Fangling Gong
Bingjie Wang
Yanan Du
Guanghui Ma
Matthias W. Amerein
Tie Xia
Yan Shi
A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
description The origin of Fc receptor-based phagocytosis is unknown, although plasma lipid redistribution after solid structure binding induces similar phagocytic signaling. Here, Mu et al. show that PIP2 accumulation from plasma membrane deformation recruits Moesin to trigger receptor-independent phagocytosis.
format article
author Libing Mu
Zhongyuan Tu
Lin Miao
Hefei Ruan
Ning Kang
Yongzhen Hei
Jiahuan Chen
Wei Wei
Fangling Gong
Bingjie Wang
Yanan Du
Guanghui Ma
Matthias W. Amerein
Tie Xia
Yan Shi
author_facet Libing Mu
Zhongyuan Tu
Lin Miao
Hefei Ruan
Ning Kang
Yongzhen Hei
Jiahuan Chen
Wei Wei
Fangling Gong
Bingjie Wang
Yanan Du
Guanghui Ma
Matthias W. Amerein
Tie Xia
Yan Shi
author_sort Libing Mu
title A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
title_short A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
title_full A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
title_fullStr A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
title_full_unstemmed A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
title_sort phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/78cb416c59cf49738095c6581a4fef6f
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