Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients

The advanced platelet parameters Immature Platelet Fraction and Immature Platelet Fraction Count have been implemented in clinical practice as measures of thrombopoietic activity, mainly in hematologic disorders that cause thrombocytopenia. The purpose of this observational study was to examine thro...

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Autores principales:	Ikkoh Yasuda, Nobuo Saito, Motoi Suzuki, Dorcas Valencia Umipig, Rontgene M. Solante, Ferdinand De Guzman, Ana Ria Sayo, Michio Yasunami, Nobuo Koizumi, Emi Kitashoji, Kentaro Sakashita, Chris Fook Sheng Ng, Chris Smith, Koya Ariyoshi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78cc926f1f224daf975543ab8a259352
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spelling	oai:doaj.org-article:78cc926f1f224daf975543ab8a2593522021-11-11T06:44:22ZUnique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients1932-6203https://doaj.org/article/78cc926f1f224daf975543ab8a2593522021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559939/?tool=EBIhttps://doaj.org/toc/1932-6203The advanced platelet parameters Immature Platelet Fraction and Immature Platelet Fraction Count have been implemented in clinical practice as measures of thrombopoietic activity, mainly in hematologic disorders that cause thrombocytopenia. The purpose of this observational study was to examine thrombopoiesis as reflected by these 2 new CBC parameters in patients infected with dengue. The study was conducted in infectious disease referral hospital in Metro Manila, the Philippines. We enrolled hospitalized patients at admission who were diagnosed with acute dengue or community acquired bacterial infection (CABI). Immature Platelet Fraction (IPF) and Immature Platelet Fraction Count were evaluated at admission and during hospitalization. A total of 606 patients were enrolled from May 1, 2017 to June 1, 2018. The participants consisted of 152 patients with dengue infection, 180 confirmed CABI, and 274 suspected CABI patients. At admission, the percent IPF (IPF%) of the patients with dengue was significantly higher than that of the confirmed CABI patients (median 3.7% versus 1.9%; p <0.001). In a time course evaluation, there was no significant difference of IPF% between the patients with dengue infection and the confirmed CABI patients in the febrile phase (median 1.9% versus 2.4%; p = 0.488), however, the IPF% of the patients with dengue infection increased to be significantly higher than that of the confirmed CABI patients in the critical phase (median 5.2% versus 2.2%; p <0.001). Our study elucidated the unique characteristics and time-course trends of IPF percent and number (IPF#) in the patients with dengue infection. IPF% and IPF# are potentially valuable parameters in dengue and further investigation is required for the optimal use in clinical practice.Ikkoh YasudaNobuo SaitoMotoi SuzukiDorcas Valencia UmipigRontgene M. SolanteFerdinand De GuzmanAna Ria SayoMichio YasunamiNobuo KoizumiEmi KitashojiKentaro SakashitaChris Fook Sheng NgChris SmithKoya AriyoshiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ikkoh Yasuda Nobuo Saito Motoi Suzuki Dorcas Valencia Umipig Rontgene M. Solante Ferdinand De Guzman Ana Ria Sayo Michio Yasunami Nobuo Koizumi Emi Kitashoji Kentaro Sakashita Chris Fook Sheng Ng Chris Smith Koya Ariyoshi Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
description	The advanced platelet parameters Immature Platelet Fraction and Immature Platelet Fraction Count have been implemented in clinical practice as measures of thrombopoietic activity, mainly in hematologic disorders that cause thrombocytopenia. The purpose of this observational study was to examine thrombopoiesis as reflected by these 2 new CBC parameters in patients infected with dengue. The study was conducted in infectious disease referral hospital in Metro Manila, the Philippines. We enrolled hospitalized patients at admission who were diagnosed with acute dengue or community acquired bacterial infection (CABI). Immature Platelet Fraction (IPF) and Immature Platelet Fraction Count were evaluated at admission and during hospitalization. A total of 606 patients were enrolled from May 1, 2017 to June 1, 2018. The participants consisted of 152 patients with dengue infection, 180 confirmed CABI, and 274 suspected CABI patients. At admission, the percent IPF (IPF%) of the patients with dengue was significantly higher than that of the confirmed CABI patients (median 3.7% versus 1.9%; p <0.001). In a time course evaluation, there was no significant difference of IPF% between the patients with dengue infection and the confirmed CABI patients in the febrile phase (median 1.9% versus 2.4%; p = 0.488), however, the IPF% of the patients with dengue infection increased to be significantly higher than that of the confirmed CABI patients in the critical phase (median 5.2% versus 2.2%; p <0.001). Our study elucidated the unique characteristics and time-course trends of IPF percent and number (IPF#) in the patients with dengue infection. IPF% and IPF# are potentially valuable parameters in dengue and further investigation is required for the optimal use in clinical practice.
format	article
author	Ikkoh Yasuda Nobuo Saito Motoi Suzuki Dorcas Valencia Umipig Rontgene M. Solante Ferdinand De Guzman Ana Ria Sayo Michio Yasunami Nobuo Koizumi Emi Kitashoji Kentaro Sakashita Chris Fook Sheng Ng Chris Smith Koya Ariyoshi
author_facet	Ikkoh Yasuda Nobuo Saito Motoi Suzuki Dorcas Valencia Umipig Rontgene M. Solante Ferdinand De Guzman Ana Ria Sayo Michio Yasunami Nobuo Koizumi Emi Kitashoji Kentaro Sakashita Chris Fook Sheng Ng Chris Smith Koya Ariyoshi
author_sort	Ikkoh Yasuda
title	Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
title_short	Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
title_full	Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
title_fullStr	Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
title_full_unstemmed	Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
title_sort	unique characteristics of new complete blood count parameters, the immature platelet fraction and the immature platelet fraction count, in dengue patients
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/78cc926f1f224daf975543ab8a259352
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Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients

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