Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice

Abstract The roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models. In the first, global Kiss1r-null and control mice w...

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Autores principales:	Sarah Delmas, Robert Porteous, Dave H. Bergin, Allan E. Herbison
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78cda37fd14844b8bfc4e7191f312f38
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spelling	oai:doaj.org-article:78cda37fd14844b8bfc4e7191f312f382021-12-02T11:40:54ZAltered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice10.1038/s41598-018-21042-42045-2322https://doaj.org/article/78cda37fd14844b8bfc4e7191f312f382018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21042-4https://doaj.org/toc/2045-2322Abstract The roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models. In the first, global Kiss1r-null and control mice were gonadectomized (GDX KISS1R-KO). In the second, KISS1R signalling was rescued selectively in gonadotropin-releasing hormone neurons to generate Kiss1r-null mice with normal testosterone levels (intact KISS1R-KO). Intact KISS1R-KO rescue mice were found to spend twice as much time in the open arms of the elevated plus maze (EPM) compared to controls (P < 0.01). GDX KISS1R-KO mice showed a similar but less pronounced trend. No differences were detected between intact KISS1R-KO mice and controls in the open field test (OFT), although a marked reduction in time spent in the centre quadrant was observed for all GDX mice (P < 0.001). No effects of KISS1R deletion or gonadectomy were detected in the Morris water maze. These observations demonstrate that KISS1R signalling impacts upon anxiogenic neural circuits operative in the EPM, while gonadal steroids appear important for anxiety behaviour observed in the OFT. The potential anxiogenic role of kisspeptin may need to be considered in the development of kisspeptin analogs for the clinic.Sarah DelmasRobert PorteousDave H. BerginAllan E. HerbisonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah Delmas Robert Porteous Dave H. Bergin Allan E. Herbison Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
description	Abstract The roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models. In the first, global Kiss1r-null and control mice were gonadectomized (GDX KISS1R-KO). In the second, KISS1R signalling was rescued selectively in gonadotropin-releasing hormone neurons to generate Kiss1r-null mice with normal testosterone levels (intact KISS1R-KO). Intact KISS1R-KO rescue mice were found to spend twice as much time in the open arms of the elevated plus maze (EPM) compared to controls (P < 0.01). GDX KISS1R-KO mice showed a similar but less pronounced trend. No differences were detected between intact KISS1R-KO mice and controls in the open field test (OFT), although a marked reduction in time spent in the centre quadrant was observed for all GDX mice (P < 0.001). No effects of KISS1R deletion or gonadectomy were detected in the Morris water maze. These observations demonstrate that KISS1R signalling impacts upon anxiogenic neural circuits operative in the EPM, while gonadal steroids appear important for anxiety behaviour observed in the OFT. The potential anxiogenic role of kisspeptin may need to be considered in the development of kisspeptin analogs for the clinic.
format	article
author	Sarah Delmas Robert Porteous Dave H. Bergin Allan E. Herbison
author_facet	Sarah Delmas Robert Porteous Dave H. Bergin Allan E. Herbison
author_sort	Sarah Delmas
title	Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
title_short	Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
title_full	Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
title_fullStr	Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
title_full_unstemmed	Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
title_sort	altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/78cda37fd14844b8bfc4e7191f312f38
work_keys_str_mv	AT sarahdelmas alteredaspectsofanxietyrelatedbehaviorinkisspeptinreceptordeletedmalemice AT robertporteous alteredaspectsofanxietyrelatedbehaviorinkisspeptinreceptordeletedmalemice AT davehbergin alteredaspectsofanxietyrelatedbehaviorinkisspeptinreceptordeletedmalemice AT allaneherbison alteredaspectsofanxietyrelatedbehaviorinkisspeptinreceptordeletedmalemice
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Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice

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