Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online

Background: Dietary supplements are popular among US consumers and claim to address a variety of conditions, including acne. Acne supplements containing vitamin A are of particular interest, due to the potentially teratogenic effects of vitamin A doses over 10,000 IU. Objective: This study exami...

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Autores principales:	Dina Zamil, Emily Burns, Ariadna Perez-Sanchez, Milbrey Parke, Rajani Katta
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	vitamin A acne supplements teratogenicity pregnancy labeling Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/78ce92ad3d8a4218bcb3ec3300995c63
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spelling	oai:doaj.org-article:78ce92ad3d8a4218bcb3ec3300995c632021-11-17T08:27:53ZRisk of Birth Defects From Vitamin A “Acne Supplements” Sold Online10.5826/dpc.1103a752160-9381https://doaj.org/article/78ce92ad3d8a4218bcb3ec3300995c632021-05-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1580https://doaj.org/toc/2160-9381 Background: Dietary supplements are popular among US consumers and claim to address a variety of conditions, including acne. Acne supplements containing vitamin A are of particular interest, due to the potentially teratogenic effects of vitamin A doses over 10,000 IU. Objective: This study examined dosage, pregnancy risks, and labeling of vitamin A-containing acne supplements available online. Methods: An Internet search of acne supplements sold online was conducted between March and May 2020. Supplement labels and websites were analyzed for vitamin A content and pregnancy warnings, and then divided into categories based on dosage and teratogenic risk. Results: A total of 49 acne supplements was found, and of these 26 (53%) contain vitamin A. Three supplements are likely teratogenic, 4 contain vitamin A doses exceeding the daily level of intake that meets the nutritional needs of most people, and 15 have an unknown teratogenic risk. Among the 6 supplements with over 10,000 IU vitamin A, 2 have no pregnancy warning at all, including the supplement with the highest vitamin A dose found in this study. Conclusions: Dietary supplements are not subject to the same stringent regulations as drugs, and as such, consumers may be unaware of pregnancy risks. Furthermore, FDA requirements on labeling of vitamin A supplements may lead to consumer confusion regarding dosage. As such, we encourage stricter labeling requirements for vitamin A-containing supplements, including pregnancy warnings for high-dose supplements and clearer dosage labeling. Dina ZamilEmily BurnsAriadna Perez-SanchezMilbrey ParkeRajani KattaMattioli1885articlevitamin Aacne supplementsteratogenicitypregnancylabelingDermatologyRL1-803ENDermatology Practical & Conceptual (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin A acne supplements teratogenicity pregnancy labeling Dermatology RL1-803
spellingShingle	vitamin A acne supplements teratogenicity pregnancy labeling Dermatology RL1-803 Dina Zamil Emily Burns Ariadna Perez-Sanchez Milbrey Parke Rajani Katta Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online
description	Background: Dietary supplements are popular among US consumers and claim to address a variety of conditions, including acne. Acne supplements containing vitamin A are of particular interest, due to the potentially teratogenic effects of vitamin A doses over 10,000 IU. Objective: This study examined dosage, pregnancy risks, and labeling of vitamin A-containing acne supplements available online. Methods: An Internet search of acne supplements sold online was conducted between March and May 2020. Supplement labels and websites were analyzed for vitamin A content and pregnancy warnings, and then divided into categories based on dosage and teratogenic risk. Results: A total of 49 acne supplements was found, and of these 26 (53%) contain vitamin A. Three supplements are likely teratogenic, 4 contain vitamin A doses exceeding the daily level of intake that meets the nutritional needs of most people, and 15 have an unknown teratogenic risk. Among the 6 supplements with over 10,000 IU vitamin A, 2 have no pregnancy warning at all, including the supplement with the highest vitamin A dose found in this study. Conclusions: Dietary supplements are not subject to the same stringent regulations as drugs, and as such, consumers may be unaware of pregnancy risks. Furthermore, FDA requirements on labeling of vitamin A supplements may lead to consumer confusion regarding dosage. As such, we encourage stricter labeling requirements for vitamin A-containing supplements, including pregnancy warnings for high-dose supplements and clearer dosage labeling.
format	article
author	Dina Zamil Emily Burns Ariadna Perez-Sanchez Milbrey Parke Rajani Katta
author_facet	Dina Zamil Emily Burns Ariadna Perez-Sanchez Milbrey Parke Rajani Katta
author_sort	Dina Zamil
title	Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online
title_short	Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online
title_full	Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online
title_fullStr	Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online
title_full_unstemmed	Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online
title_sort	risk of birth defects from vitamin a “acne supplements” sold online
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/78ce92ad3d8a4218bcb3ec3300995c63
work_keys_str_mv	AT dinazamil riskofbirthdefectsfromvitaminaacnesupplementssoldonline AT emilyburns riskofbirthdefectsfromvitaminaacnesupplementssoldonline AT ariadnaperezsanchez riskofbirthdefectsfromvitaminaacnesupplementssoldonline AT milbreyparke riskofbirthdefectsfromvitaminaacnesupplementssoldonline AT rajanikatta riskofbirthdefectsfromvitaminaacnesupplementssoldonline
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Risk of Birth Defects From Vitamin A “Acne Supplements” Sold Online

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