Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

Natural supplies of bryostatin, a compound in clinical trials for Alzheimer’s disease, cancer, and HIV, are scarce. Here, the authors perform molecular dynamics simulations to understand how bryostatin interacts with membrane-bound protein kinase C, offering insights for the design of bryostatin ana...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Steven M. Ryckbosch, Paul A. Wender, Vijay S. Pande
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78cf93730c7546aa81864384d812eaa5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:78cf93730c7546aa81864384d812eaa5
record_format	dspace
spelling	oai:doaj.org-article:78cf93730c7546aa81864384d812eaa52021-12-02T13:24:05ZMolecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes10.1038/s41467-016-0015-82041-1723https://doaj.org/article/78cf93730c7546aa81864384d812eaa52017-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-016-0015-8https://doaj.org/toc/2041-1723Natural supplies of bryostatin, a compound in clinical trials for Alzheimer’s disease, cancer, and HIV, are scarce. Here, the authors perform molecular dynamics simulations to understand how bryostatin interacts with membrane-bound protein kinase C, offering insights for the design of bryostatin analogs.Steven M. RyckboschPaul A. WenderVijay S. PandeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steven M. Ryckbosch Paul A. Wender Vijay S. Pande Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
description	Natural supplies of bryostatin, a compound in clinical trials for Alzheimer’s disease, cancer, and HIV, are scarce. Here, the authors perform molecular dynamics simulations to understand how bryostatin interacts with membrane-bound protein kinase C, offering insights for the design of bryostatin analogs.
format	article
author	Steven M. Ryckbosch Paul A. Wender Vijay S. Pande
author_facet	Steven M. Ryckbosch Paul A. Wender Vijay S. Pande
author_sort	Steven M. Ryckbosch
title	Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
title_short	Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
title_full	Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
title_fullStr	Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
title_full_unstemmed	Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
title_sort	molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78cf93730c7546aa81864384d812eaa5
work_keys_str_mv	AT stevenmryckbosch moleculardynamicssimulationsrevealligandcontrolledpositioningofaperipheralproteincomplexinmembranes AT paulawender moleculardynamicssimulationsrevealligandcontrolledpositioningofaperipheralproteincomplexinmembranes AT vijayspande moleculardynamicssimulationsrevealligandcontrolledpositioningofaperipheralproteincomplexinmembranes
_version_	1718393159522713600

Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

Ejemplares similares