Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes

Natural supplies of bryostatin, a compound in clinical trials for Alzheimer’s disease, cancer, and HIV, are scarce. Here, the authors perform molecular dynamics simulations to understand how bryostatin interacts with membrane-bound protein kinase C, offering insights for the design of bryostatin ana...

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Autores principales: Steven M. Ryckbosch, Paul A. Wender, Vijay S. Pande
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/78cf93730c7546aa81864384d812eaa5
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