Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion

Abstract Parkinson’s disease (PD) alters cortico-basal ganglia-thalamic circuitry and susceptibility to an illusion of bodily awareness, the Rubber Hand Illusion (RHI). Bodily awareness is thought to result from multisensory integration in a predominantly cortical network; the role of subcortical co...

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Autores principales:	Catherine Ding, Colin J. Palmer, Jakob Hohwy, George J. Youssef, Bryan Paton, Naotsugu Tsuchiya, Julie C. Stout, Dominic Thyagarajan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Rubber Hand Illusion (RHI) Asynchronous Condition Proprioceptive Drift Illusion Scores Stroke Statistics Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78d90c15958f48bd8873436cbc00cdae
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spelling	oai:doaj.org-article:78d90c15958f48bd8873436cbc00cdae2021-12-02T15:08:36ZDeep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion10.1038/s41598-018-31867-82045-2322https://doaj.org/article/78d90c15958f48bd8873436cbc00cdae2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31867-8https://doaj.org/toc/2045-2322Abstract Parkinson’s disease (PD) alters cortico-basal ganglia-thalamic circuitry and susceptibility to an illusion of bodily awareness, the Rubber Hand Illusion (RHI). Bodily awareness is thought to result from multisensory integration in a predominantly cortical network; the role of subcortical connections is unknown. We studied the effect of modulating cortico-subcortical circuitry on multisensory integration for bodily awareness in 24 PD patients treated with subthalamic nucleus (STN) deep brain stimulation (DBS), in comparison to 21 healthy volunteers, using the RHI experiment. Typically, synchronous visuo-tactile cues induce a false perception of touch on the rubber hand as if it were the subject’s hand, whereas asynchronous visuo-tactile cues do not. However, we found that in the asynchronous condition, patients in the off-stimulation state did not reject the RHI as strongly as healthy controls; patients’ rejection of the RHI strengthened when STN-DBS was switched on, although it remained weaker than that of controls. Patients in the off-stimulation state also misjudged the position of their hand, indicating it to be closer to the rubber hand than controls. However, STN-DBS did not affect proprioceptive judgements or subsequent arm movements altered by the perceptual effects of the illusion. Our findings support the idea that the STN and subcortical connections have a key role in multisensory integration for bodily awareness. Decision-making in multisensory bodily illusions is discussed.Catherine DingColin J. PalmerJakob HohwyGeorge J. YoussefBryan PatonNaotsugu TsuchiyaJulie C. StoutDominic ThyagarajanNature PortfolioarticleRubber Hand Illusion (RHI)Asynchronous ConditionProprioceptive DriftIllusion ScoresStroke StatisticsMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rubber Hand Illusion (RHI) Asynchronous Condition Proprioceptive Drift Illusion Scores Stroke Statistics Medicine R Science Q
spellingShingle	Rubber Hand Illusion (RHI) Asynchronous Condition Proprioceptive Drift Illusion Scores Stroke Statistics Medicine R Science Q Catherine Ding Colin J. Palmer Jakob Hohwy George J. Youssef Bryan Paton Naotsugu Tsuchiya Julie C. Stout Dominic Thyagarajan Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion
description	Abstract Parkinson’s disease (PD) alters cortico-basal ganglia-thalamic circuitry and susceptibility to an illusion of bodily awareness, the Rubber Hand Illusion (RHI). Bodily awareness is thought to result from multisensory integration in a predominantly cortical network; the role of subcortical connections is unknown. We studied the effect of modulating cortico-subcortical circuitry on multisensory integration for bodily awareness in 24 PD patients treated with subthalamic nucleus (STN) deep brain stimulation (DBS), in comparison to 21 healthy volunteers, using the RHI experiment. Typically, synchronous visuo-tactile cues induce a false perception of touch on the rubber hand as if it were the subject’s hand, whereas asynchronous visuo-tactile cues do not. However, we found that in the asynchronous condition, patients in the off-stimulation state did not reject the RHI as strongly as healthy controls; patients’ rejection of the RHI strengthened when STN-DBS was switched on, although it remained weaker than that of controls. Patients in the off-stimulation state also misjudged the position of their hand, indicating it to be closer to the rubber hand than controls. However, STN-DBS did not affect proprioceptive judgements or subsequent arm movements altered by the perceptual effects of the illusion. Our findings support the idea that the STN and subcortical connections have a key role in multisensory integration for bodily awareness. Decision-making in multisensory bodily illusions is discussed.
format	article
author	Catherine Ding Colin J. Palmer Jakob Hohwy George J. Youssef Bryan Paton Naotsugu Tsuchiya Julie C. Stout Dominic Thyagarajan
author_facet	Catherine Ding Colin J. Palmer Jakob Hohwy George J. Youssef Bryan Paton Naotsugu Tsuchiya Julie C. Stout Dominic Thyagarajan
author_sort	Catherine Ding
title	Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion
title_short	Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion
title_full	Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion
title_fullStr	Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion
title_full_unstemmed	Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion
title_sort	deep brain stimulation for parkinson’s disease changes perception in the rubber hand illusion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/78d90c15958f48bd8873436cbc00cdae
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Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion

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