Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

The immune response to Zika virus is required to curtail the infection and avoid immunopathology, but may be involved in the associated pathophysiology. Here the authors show that viral persistence and tissue tropism is shaped by an early innate immune response in a pigtail macaque model of infectio...

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Autores principales:	Megan A. O’Connor, Jennifer Tisoncik-Go, Thomas B. Lewis, Charlene J. Miller, Debra Bratt, Cassie R. Moats, Paul T. Edlefsen, Jeremy Smedley, Nichole R. Klatt, Michael Gale, Deborah Heydenburg Fuller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78dc029ed4b2439e9cffb503a9b5876b
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spelling	oai:doaj.org-article:78dc029ed4b2439e9cffb503a9b5876b2021-12-02T14:41:29ZEarly cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques10.1038/s41467-018-05826-w2041-1723https://doaj.org/article/78dc029ed4b2439e9cffb503a9b5876b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05826-whttps://doaj.org/toc/2041-1723The immune response to Zika virus is required to curtail the infection and avoid immunopathology, but may be involved in the associated pathophysiology. Here the authors show that viral persistence and tissue tropism is shaped by an early innate immune response in a pigtail macaque model of infection.Megan A. O’ConnorJennifer Tisoncik-GoThomas B. LewisCharlene J. MillerDebra BrattCassie R. MoatsPaul T. EdlefsenJeremy SmedleyNichole R. KlattMichael GaleDeborah Heydenburg FullerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Megan A. O’Connor Jennifer Tisoncik-Go Thomas B. Lewis Charlene J. Miller Debra Bratt Cassie R. Moats Paul T. Edlefsen Jeremy Smedley Nichole R. Klatt Michael Gale Deborah Heydenburg Fuller Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques
description	The immune response to Zika virus is required to curtail the infection and avoid immunopathology, but may be involved in the associated pathophysiology. Here the authors show that viral persistence and tissue tropism is shaped by an early innate immune response in a pigtail macaque model of infection.
format	article
author	Megan A. O’Connor Jennifer Tisoncik-Go Thomas B. Lewis Charlene J. Miller Debra Bratt Cassie R. Moats Paul T. Edlefsen Jeremy Smedley Nichole R. Klatt Michael Gale Deborah Heydenburg Fuller
author_facet	Megan A. O’Connor Jennifer Tisoncik-Go Thomas B. Lewis Charlene J. Miller Debra Bratt Cassie R. Moats Paul T. Edlefsen Jeremy Smedley Nichole R. Klatt Michael Gale Deborah Heydenburg Fuller
author_sort	Megan A. O’Connor
title	Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques
title_short	Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques
title_full	Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques
title_fullStr	Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques
title_full_unstemmed	Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques
title_sort	early cellular innate immune responses drive zika viral persistence and tissue tropism in pigtail macaques
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/78dc029ed4b2439e9cffb503a9b5876b
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Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

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