Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier

Abstract Studies related to loading ability and delivery of clinically used first-line anti-tuberculosis drugs (ATDs) such as isoniazid, rifampicin, pyrazinamide and streptomycin on the surface of starch-derived bulk and nanopolyurethanes (SBPUs and SNPUs) as drug delivery systems (DDS) have been fo...

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Autores principales:	Shivang K. Desai, Dhananjoy Mondal, Smritilekha Bera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78dc5481a5cc47e3b56e364b0bf0ad70
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spelling	oai:doaj.org-article:78dc5481a5cc47e3b56e364b0bf0ad702021-12-02T14:26:20ZPolyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier10.1038/s41598-021-86767-12045-2322https://doaj.org/article/78dc5481a5cc47e3b56e364b0bf0ad702021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86767-1https://doaj.org/toc/2045-2322Abstract Studies related to loading ability and delivery of clinically used first-line anti-tuberculosis drugs (ATDs) such as isoniazid, rifampicin, pyrazinamide and streptomycin on the surface of starch-derived bulk and nanopolyurethanes (SBPUs and SNPUs) as drug delivery systems (DDS) have been focused to minimise or remove the drug-associated adverse effects. The efficiencies of nanopolyurethanes obtained from the differently substituted cyclic aliphatic and aromatic isocyanates have been studied for drug loading and release purposes. Different advanced instrumental techniques analysed the structural and morphological properties, thermal stability and crystallinity of the starch nanopolyurethans. Average particle sizes ranging from 27.35–42.38 nm to 126.89–218.60 nm for starch nanopolyurethans, SNPU3i and SNPU4i, respectively, were determined by high-resolution transmission electron microscopy. Similarly, the loading efficiency of ATDs to the surfaces of SNPUs and SBPUs was observed in the range of 60–97% while ATDs-loaded SNPUs showed a sustainable release profile for all ATDs except for streptomycin. However, most SBPUs provided burst-release for all the above-mentioned ATDs in pH-dependent studies. The anti-tuberculosis assay against the Mycobacterium tuberculosis H37Rv strain revealed that streptomycin-loaded SNPU4i and isoniazid-loaded SNPU7i are approximately 42 and 7 times more active than the native streptomycin and isoniazid, respectively.Shivang K. DesaiDhananjoy MondalSmritilekha BeraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shivang K. Desai Dhananjoy Mondal Smritilekha Bera Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier
description	Abstract Studies related to loading ability and delivery of clinically used first-line anti-tuberculosis drugs (ATDs) such as isoniazid, rifampicin, pyrazinamide and streptomycin on the surface of starch-derived bulk and nanopolyurethanes (SBPUs and SNPUs) as drug delivery systems (DDS) have been focused to minimise or remove the drug-associated adverse effects. The efficiencies of nanopolyurethanes obtained from the differently substituted cyclic aliphatic and aromatic isocyanates have been studied for drug loading and release purposes. Different advanced instrumental techniques analysed the structural and morphological properties, thermal stability and crystallinity of the starch nanopolyurethans. Average particle sizes ranging from 27.35–42.38 nm to 126.89–218.60 nm for starch nanopolyurethans, SNPU3i and SNPU4i, respectively, were determined by high-resolution transmission electron microscopy. Similarly, the loading efficiency of ATDs to the surfaces of SNPUs and SBPUs was observed in the range of 60–97% while ATDs-loaded SNPUs showed a sustainable release profile for all ATDs except for streptomycin. However, most SBPUs provided burst-release for all the above-mentioned ATDs in pH-dependent studies. The anti-tuberculosis assay against the Mycobacterium tuberculosis H37Rv strain revealed that streptomycin-loaded SNPU4i and isoniazid-loaded SNPU7i are approximately 42 and 7 times more active than the native streptomycin and isoniazid, respectively.
format	article
author	Shivang K. Desai Dhananjoy Mondal Smritilekha Bera
author_facet	Shivang K. Desai Dhananjoy Mondal Smritilekha Bera
author_sort	Shivang K. Desai
title	Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier
title_short	Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier
title_full	Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier
title_fullStr	Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier
title_full_unstemmed	Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier
title_sort	polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/78dc5481a5cc47e3b56e364b0bf0ad70
work_keys_str_mv	AT shivangkdesai polyurethanefunctionalizedstarchnanocrystalsasantituberculosisdrugcarrier AT dhananjoymondal polyurethanefunctionalizedstarchnanocrystalsasantituberculosisdrugcarrier AT smritilekhabera polyurethanefunctionalizedstarchnanocrystalsasantituberculosisdrugcarrier
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Polyurethane-functionalized starch nanocrystals as anti-tuberculosis drug carrier

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