Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

Exosomes, vesicles secreted by cancer cells, have a role in cancer progression but the mechanisms regulating their biogenesis are mostly unknown. Here the authors show that PKM2, a rate-limiting glycolytic enzyme overexpressed in cancer cells, mediates exosomes exocytosis by phosphorylating SNAP-23.

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Autores principales:	Yao Wei, Dong Wang, Fangfang Jin, Zhen Bian, Limin Li, Hongwei Liang, Mingzhen Li, Lei Shi, Chaoyun Pan, Dihan Zhu, Xi Chen, Gang Hu, Yuan Liu, Chen-Yu Zhang, Ke Zen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/78de0eef122d4d1f9e62f2a3879f5b80
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spelling	oai:doaj.org-article:78de0eef122d4d1f9e62f2a3879f5b802021-12-02T14:42:19ZPyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 2310.1038/ncomms140412041-1723https://doaj.org/article/78de0eef122d4d1f9e62f2a3879f5b802017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14041https://doaj.org/toc/2041-1723Exosomes, vesicles secreted by cancer cells, have a role in cancer progression but the mechanisms regulating their biogenesis are mostly unknown. Here the authors show that PKM2, a rate-limiting glycolytic enzyme overexpressed in cancer cells, mediates exosomes exocytosis by phosphorylating SNAP-23.Yao WeiDong WangFangfang JinZhen BianLimin LiHongwei LiangMingzhen LiLei ShiChaoyun PanDihan ZhuXi ChenGang HuYuan LiuChen-Yu ZhangKe ZenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao Wei Dong Wang Fangfang Jin Zhen Bian Limin Li Hongwei Liang Mingzhen Li Lei Shi Chaoyun Pan Dihan Zhu Xi Chen Gang Hu Yuan Liu Chen-Yu Zhang Ke Zen Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
description	Exosomes, vesicles secreted by cancer cells, have a role in cancer progression but the mechanisms regulating their biogenesis are mostly unknown. Here the authors show that PKM2, a rate-limiting glycolytic enzyme overexpressed in cancer cells, mediates exosomes exocytosis by phosphorylating SNAP-23.
format	article
author	Yao Wei Dong Wang Fangfang Jin Zhen Bian Limin Li Hongwei Liang Mingzhen Li Lei Shi Chaoyun Pan Dihan Zhu Xi Chen Gang Hu Yuan Liu Chen-Yu Zhang Ke Zen
author_facet	Yao Wei Dong Wang Fangfang Jin Zhen Bian Limin Li Hongwei Liang Mingzhen Li Lei Shi Chaoyun Pan Dihan Zhu Xi Chen Gang Hu Yuan Liu Chen-Yu Zhang Ke Zen
author_sort	Yao Wei
title	Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
title_short	Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
title_full	Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
title_fullStr	Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
title_full_unstemmed	Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
title_sort	pyruvate kinase type m2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/78de0eef122d4d1f9e62f2a3879f5b80
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Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

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