The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.

Head and neck squamous cell carcinoma (HNSCC) is known to cause substantial immunosuppression. The present study was designed to characterize blood leukocyte activation in HNSCC and to investigate if the individual activation pattern could be related to tumor progress and survival. The leukocyte act...

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Autores principales:	Camilla Rydberg Millrud, Anne Månsson Kvarnhammar, Rolf Uddman, Sven Björnsson, Kristian Riesbeck, Lars Olaf Cardell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78dfafca6d9e445b8111affc6ed0d8d4
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spelling	oai:doaj.org-article:78dfafca6d9e445b8111affc6ed0d8d42021-11-18T08:05:47ZThe activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.1932-620310.1371/journal.pone.0051120https://doaj.org/article/78dfafca6d9e445b8111affc6ed0d8d42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251433/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Head and neck squamous cell carcinoma (HNSCC) is known to cause substantial immunosuppression. The present study was designed to characterize blood leukocyte activation in HNSCC and to investigate if the individual activation pattern could be related to tumor progress and survival. The leukocyte activation profile of HNSCC patients and healthy controls was assessed with flow cytometry. HNSCC patients displayed increased numbers of monocytes, neutrophils and total leukocytes as well as an enhanced neutrophil/lymphocyte ratio. In addition, patients had a higher percentage of CD69(+), CD71(+) and CD98(+) T cell subsets and NK cells, and a reduced expression of L-selectin in CD14(high)CD16(+) monocytes and neutrophils, when compared to controls. These changes could be correlated to both tumor burden and spread to lymph nodes. Among the cancer patients an increased neutrophil/lymphocyte ratio, a low neutrophil and CD14(high) CD16(+) monocyte activation state and an elevated CD4/CD8 ratio were related to poor survival. In contrast, a high percentage of CD98(+) Th cells appeared to be associated with a better outcome. Taken together, the present data indicate that HNSCC causes activation of blood leukocytes and that the individual activation pattern can be linked to prognosis.Camilla Rydberg MillrudAnne Månsson KvarnhammarRolf UddmanSven BjörnssonKristian RiesbeckLars Olaf CardellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51120 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camilla Rydberg Millrud Anne Månsson Kvarnhammar Rolf Uddman Sven Björnsson Kristian Riesbeck Lars Olaf Cardell The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
description	Head and neck squamous cell carcinoma (HNSCC) is known to cause substantial immunosuppression. The present study was designed to characterize blood leukocyte activation in HNSCC and to investigate if the individual activation pattern could be related to tumor progress and survival. The leukocyte activation profile of HNSCC patients and healthy controls was assessed with flow cytometry. HNSCC patients displayed increased numbers of monocytes, neutrophils and total leukocytes as well as an enhanced neutrophil/lymphocyte ratio. In addition, patients had a higher percentage of CD69(+), CD71(+) and CD98(+) T cell subsets and NK cells, and a reduced expression of L-selectin in CD14(high)CD16(+) monocytes and neutrophils, when compared to controls. These changes could be correlated to both tumor burden and spread to lymph nodes. Among the cancer patients an increased neutrophil/lymphocyte ratio, a low neutrophil and CD14(high) CD16(+) monocyte activation state and an elevated CD4/CD8 ratio were related to poor survival. In contrast, a high percentage of CD98(+) Th cells appeared to be associated with a better outcome. Taken together, the present data indicate that HNSCC causes activation of blood leukocytes and that the individual activation pattern can be linked to prognosis.
format	article
author	Camilla Rydberg Millrud Anne Månsson Kvarnhammar Rolf Uddman Sven Björnsson Kristian Riesbeck Lars Olaf Cardell
author_facet	Camilla Rydberg Millrud Anne Månsson Kvarnhammar Rolf Uddman Sven Björnsson Kristian Riesbeck Lars Olaf Cardell
author_sort	Camilla Rydberg Millrud
title	The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
title_short	The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
title_full	The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
title_fullStr	The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
title_full_unstemmed	The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
title_sort	activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/78dfafca6d9e445b8111affc6ed0d8d4
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The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.

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