Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease

Abstract Premature immune ageing, including thymic atrophy, is observed in patients with chronic kidney disease (CKD). Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), which are mineral and bone disorder (MBD)-related factors, affect immune cells and possibly cause thymic atrophy....

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Autores principales:	Kenichiro Iio, Daijiro Kabata, Rei Iio, Yosuke Imai, Masaki Hatanaka, Hiroki Omori, Yoshihiko Hoshida, Yukihiko Saeki, Ayumi Shintani, Takayuki Hamano, Yoshitaka Isaka, Yutaka Ando
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78e139fff6524f55999681e7229fc591
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spelling	oai:doaj.org-article:78e139fff6524f55999681e7229fc5912021-12-02T15:08:31ZParathyroid hormone and premature thymus ageing in patients with chronic kidney disease10.1038/s41598-018-37511-92045-2322https://doaj.org/article/78e139fff6524f55999681e7229fc5912019-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-37511-9https://doaj.org/toc/2045-2322Abstract Premature immune ageing, including thymic atrophy, is observed in patients with chronic kidney disease (CKD). Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), which are mineral and bone disorder (MBD)-related factors, affect immune cells and possibly cause thymic atrophy. We examined the cross-sectional association between thymic atrophy, evaluated as the number of CD3+CD4+CD45RA+CD31+ cells [recent thymic emigrants (RTE)/μL], and MBD-related factors [(serum PTH, FGF23, and alkaline phosphatase (ALP) level] in 125 patients with non-dialysis dependent CKD. Median estimated glomerular filtration rate (eGFR) was 17 mL/min/1.73 m2. Older age (r = −0.46), male sex (r = −0.34), lower eGFR (r = 0.27), lower serum-corrected calcium (r = 0.27), higher PTH (r = −0.36), and higher ALP level (r = −0.20) were identified as determinants of lower number of RTE. In contrast, serum concentrations of FGF23 and phosphorus were not correlated with RTE. Multivariate non-linear regression analysis indicated a negative association between serum PTH and log-transformed RTE (P = 0.030, P for non-linearity = 0.124). However, the serum levels of FGF23 and ALP were not associated with RTE. In patients with CKD, serum PTH concentrations were related to thymic atrophy which contributes to immune abnormality.Kenichiro IioDaijiro KabataRei IioYosuke ImaiMasaki HatanakaHiroki OmoriYoshihiko HoshidaYukihiko SaekiAyumi ShintaniTakayuki HamanoYoshitaka IsakaYutaka AndoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenichiro Iio Daijiro Kabata Rei Iio Yosuke Imai Masaki Hatanaka Hiroki Omori Yoshihiko Hoshida Yukihiko Saeki Ayumi Shintani Takayuki Hamano Yoshitaka Isaka Yutaka Ando Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease
description	Abstract Premature immune ageing, including thymic atrophy, is observed in patients with chronic kidney disease (CKD). Parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), which are mineral and bone disorder (MBD)-related factors, affect immune cells and possibly cause thymic atrophy. We examined the cross-sectional association between thymic atrophy, evaluated as the number of CD3+CD4+CD45RA+CD31+ cells [recent thymic emigrants (RTE)/μL], and MBD-related factors [(serum PTH, FGF23, and alkaline phosphatase (ALP) level] in 125 patients with non-dialysis dependent CKD. Median estimated glomerular filtration rate (eGFR) was 17 mL/min/1.73 m2. Older age (r = −0.46), male sex (r = −0.34), lower eGFR (r = 0.27), lower serum-corrected calcium (r = 0.27), higher PTH (r = −0.36), and higher ALP level (r = −0.20) were identified as determinants of lower number of RTE. In contrast, serum concentrations of FGF23 and phosphorus were not correlated with RTE. Multivariate non-linear regression analysis indicated a negative association between serum PTH and log-transformed RTE (P = 0.030, P for non-linearity = 0.124). However, the serum levels of FGF23 and ALP were not associated with RTE. In patients with CKD, serum PTH concentrations were related to thymic atrophy which contributes to immune abnormality.
format	article
author	Kenichiro Iio Daijiro Kabata Rei Iio Yosuke Imai Masaki Hatanaka Hiroki Omori Yoshihiko Hoshida Yukihiko Saeki Ayumi Shintani Takayuki Hamano Yoshitaka Isaka Yutaka Ando
author_facet	Kenichiro Iio Daijiro Kabata Rei Iio Yosuke Imai Masaki Hatanaka Hiroki Omori Yoshihiko Hoshida Yukihiko Saeki Ayumi Shintani Takayuki Hamano Yoshitaka Isaka Yutaka Ando
author_sort	Kenichiro Iio
title	Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease
title_short	Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease
title_full	Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease
title_fullStr	Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease
title_full_unstemmed	Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease
title_sort	parathyroid hormone and premature thymus ageing in patients with chronic kidney disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/78e139fff6524f55999681e7229fc591
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Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease

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