Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Methicillin-resistant Staphylococcus aureus is estimated to cause more U.S. deaths annually than HIV/AIDS. The emergence of hypervirulent and multidrug-resistant strains has further amplified public health concern and accentuated the need for new classes of antibiotics. RNA degradation is a required...

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Auteurs principaux:	Patrick D Olson, Lisa J Kuechenmeister, Kelsi L Anderson, Sonja Daily, Karen E Beenken, Christelle M Roux, Michelle L Reniere, Tami L Lewis, William J Weiss, Mark Pulse, Phung Nguyen, Jerry W Simecka, John M Morrison, Khalid Sayood, Oluwatoyin A Asojo, Mark S Smeltzer, Eric P Skaar, Paul M Dunman
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2011
Sujets:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/78e41f54ca3e43d185ba27c4529fcda9
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Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

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