Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Methicillin-resistant Staphylococcus aureus is estimated to cause more U.S. deaths annually than HIV/AIDS. The emergence of hypervirulent and multidrug-resistant strains has further amplified public health concern and accentuated the need for new classes of antibiotics. RNA degradation is a required...

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Détails bibliographiques
Auteurs principaux: Patrick D Olson, Lisa J Kuechenmeister, Kelsi L Anderson, Sonja Daily, Karen E Beenken, Christelle M Roux, Michelle L Reniere, Tami L Lewis, William J Weiss, Mark Pulse, Phung Nguyen, Jerry W Simecka, John M Morrison, Khalid Sayood, Oluwatoyin A Asojo, Mark S Smeltzer, Eric P Skaar, Paul M Dunman
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
Sujets:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/78e41f54ca3e43d185ba27c4529fcda9
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Internet

https://doaj.org/article/78e41f54ca3e43d185ba27c4529fcda9

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