Structure-based dynamic analysis of the glycine cleavage system suggests key residues for control of a key reaction step

Han Zhang et al. report molecular dynamics simulations and mutational analysis of a key process of the E. coli glycine cleavage system, an important enzyme complex in C1 metabolism. They identify a key amino acid residue controlling the release of the swinging aminomethyl lipoate arm and increase th...

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Autores principales: Han Zhang, Yuchen Li, Jinglei Nie, Jie Ren, An-Ping Zeng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/78e895b2a82e49aea72b3a9bd99928e3
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