Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema

Abstract Protein S (PS) is a multifunctional glycoprotein that ameliorates the detrimental effects of diabetes mellitus (DM). The aim of this study was to evaluate the distribution of PS in diabetic retinopathy (DR) and diabetic macular edema (DME). This was a study of 50 eyes with DM (37 with DME,...

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Autores principales:	Masahiko Sugimoto, Mineo Kondo, Taro Yasuma, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Hisanori Imai, Makoto Nakamura, Esteban C. Gabazza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78ea5247c2fe409da661d4160201cf19
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spelling	oai:doaj.org-article:78ea5247c2fe409da661d4160201cf192021-12-02T14:59:06ZIncreased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema10.1038/s41598-021-89870-52045-2322https://doaj.org/article/78ea5247c2fe409da661d4160201cf192021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89870-5https://doaj.org/toc/2045-2322Abstract Protein S (PS) is a multifunctional glycoprotein that ameliorates the detrimental effects of diabetes mellitus (DM). The aim of this study was to evaluate the distribution of PS in diabetic retinopathy (DR) and diabetic macular edema (DME). This was a study of 50 eyes with DM (37 with DME, 6 with proliferative DR, and 7 with no DR) and 19 eyes without DM. The level of PS was measured by enzyme immunoassay and was compared between eyes with or without DM, with or without DME, and with severe DME (≥ 350 μm) or mild DME (< 350 μm). We also performed immunohistopathologic evaluations of post-mortem eyes and the cystoid lesions excised during surgery. The aqueous free PS was significantly higher with DM (7.9 ± 1.2 ng/ml, P < 0.01) than without DM (6.1 ± 0.7). The aqueous free PS was significantly elevated with DME (8.2 ± 1.2, P < 0.05) compared to proliferative DR (7.0 ± 1.0) and no DR (7.0 ± 0.7). Eyes with severe DME had significantly higher aqueous free PS than mild DME (8.5 ± 1.3 vs. 7.7 ± 1.0, P < 0.05). Immunohistochemistry showed PS in the outer plexiform layer of the retina and cystoid lesion. The higher expression of PS with DR and DME suggests that PS is involved in their pathogenesis.Masahiko SugimotoMineo KondoTaro YasumaCorina N. D’Alessandro-GabazzaMasaaki TodaHisanori ImaiMakoto NakamuraEsteban C. GabazzaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masahiko Sugimoto Mineo Kondo Taro Yasuma Corina N. D’Alessandro-Gabazza Masaaki Toda Hisanori Imai Makoto Nakamura Esteban C. Gabazza Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema
description	Abstract Protein S (PS) is a multifunctional glycoprotein that ameliorates the detrimental effects of diabetes mellitus (DM). The aim of this study was to evaluate the distribution of PS in diabetic retinopathy (DR) and diabetic macular edema (DME). This was a study of 50 eyes with DM (37 with DME, 6 with proliferative DR, and 7 with no DR) and 19 eyes without DM. The level of PS was measured by enzyme immunoassay and was compared between eyes with or without DM, with or without DME, and with severe DME (≥ 350 μm) or mild DME (< 350 μm). We also performed immunohistopathologic evaluations of post-mortem eyes and the cystoid lesions excised during surgery. The aqueous free PS was significantly higher with DM (7.9 ± 1.2 ng/ml, P < 0.01) than without DM (6.1 ± 0.7). The aqueous free PS was significantly elevated with DME (8.2 ± 1.2, P < 0.05) compared to proliferative DR (7.0 ± 1.0) and no DR (7.0 ± 0.7). Eyes with severe DME had significantly higher aqueous free PS than mild DME (8.5 ± 1.3 vs. 7.7 ± 1.0, P < 0.05). Immunohistochemistry showed PS in the outer plexiform layer of the retina and cystoid lesion. The higher expression of PS with DR and DME suggests that PS is involved in their pathogenesis.
format	article
author	Masahiko Sugimoto Mineo Kondo Taro Yasuma Corina N. D’Alessandro-Gabazza Masaaki Toda Hisanori Imai Makoto Nakamura Esteban C. Gabazza
author_facet	Masahiko Sugimoto Mineo Kondo Taro Yasuma Corina N. D’Alessandro-Gabazza Masaaki Toda Hisanori Imai Makoto Nakamura Esteban C. Gabazza
author_sort	Masahiko Sugimoto
title	Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema
title_short	Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema
title_full	Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema
title_fullStr	Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema
title_full_unstemmed	Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema
title_sort	increased expression of protein s in eyes with diabetic retinopathy and diabetic macular edema
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/78ea5247c2fe409da661d4160201cf19
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Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema

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