CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION

Acute sepsis (1-3 days after admission) has been compared with tertiary peritonitis, as a clinical variant of prolonged sepsis (7 to 42 days after admission). A total of 153 patients were enrolled into the study, including 112 cases of multiple organ dysfunction syndrome (MODS, as assessed by SOFA s...

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Autores principales:	E. Yu. Gusev, N. V. Zotova, M. A. Lazareva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	sepsis tertiary peritonitis systemic inflammation cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/78edbed40a4646b5873b3789b18026a7
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spelling	oai:doaj.org-article:78edbed40a4646b5873b3789b18026a72021-11-18T08:03:43ZCYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION1563-06252313-741X10.15789/1563-0625-2014-2-173-182https://doaj.org/article/78edbed40a4646b5873b3789b18026a72014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/683https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAcute sepsis (1-3 days after admission) has been compared with tertiary peritonitis, as a clinical variant of prolonged sepsis (7 to 42 days after admission). A total of 153 patients were enrolled into the study, including 112 cases of multiple organ dysfunction syndrome (MODS, as assessed by SOFA score), of them thirty-one with septic shock; fatal outcomes, in 48 cases. Plasma concentrations of C-reactive protein, cytokines (IL-6, IL-8, IL-10, TNFα), cortisol, troponin I, myoglobin, D-dimer were detected by means of immunochemiluminesce assay (ImmuLite). Development of systemic inflammation (SI) was evaluated by appropriate integral criteria. An association was established between SI development and critical complications in the both groups of patients. Meanwhile, hyperergic variants of SI development associated with high cytokine levels, proved to prevail in acute sepsis. On the contrary, hypoergic variants were more common in cases of tertiary peritonitis, being characterized by relatively low levels of cytokines, along with higher probability of other SI syndromes and risks of lethal outcomes. In summary, systemic inflammatory events in acute versus prolonged sepsis may proceed by different pathogenetic pathways.E. Yu. GusevN. V. ZotovaM. A. LazarevaSPb RAACIarticlesepsistertiary peritonitissystemic inflammationcytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 173-182 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	sepsis tertiary peritonitis systemic inflammation cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	sepsis tertiary peritonitis systemic inflammation cytokines Immunologic diseases. Allergy RC581-607 E. Yu. Gusev N. V. Zotova M. A. Lazareva CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION
description	Acute sepsis (1-3 days after admission) has been compared with tertiary peritonitis, as a clinical variant of prolonged sepsis (7 to 42 days after admission). A total of 153 patients were enrolled into the study, including 112 cases of multiple organ dysfunction syndrome (MODS, as assessed by SOFA score), of them thirty-one with septic shock; fatal outcomes, in 48 cases. Plasma concentrations of C-reactive protein, cytokines (IL-6, IL-8, IL-10, TNFα), cortisol, troponin I, myoglobin, D-dimer were detected by means of immunochemiluminesce assay (ImmuLite). Development of systemic inflammation (SI) was evaluated by appropriate integral criteria. An association was established between SI development and critical complications in the both groups of patients. Meanwhile, hyperergic variants of SI development associated with high cytokine levels, proved to prevail in acute sepsis. On the contrary, hypoergic variants were more common in cases of tertiary peritonitis, being characterized by relatively low levels of cytokines, along with higher probability of other SI syndromes and risks of lethal outcomes. In summary, systemic inflammatory events in acute versus prolonged sepsis may proceed by different pathogenetic pathways.
format	article
author	E. Yu. Gusev N. V. Zotova M. A. Lazareva
author_facet	E. Yu. Gusev N. V. Zotova M. A. Lazareva
author_sort	E. Yu. Gusev
title	CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION
title_short	CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION
title_full	CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION
title_fullStr	CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION
title_full_unstemmed	CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION
title_sort	cytokine response and other differences between critical phases of sepsis-associated systemic inflammation
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/78edbed40a4646b5873b3789b18026a7
work_keys_str_mv	AT eyugusev cytokineresponseandotherdifferencesbetweencriticalphasesofsepsisassociatedsystemicinflammation AT nvzotova cytokineresponseandotherdifferencesbetweencriticalphasesofsepsisassociatedsystemicinflammation AT malazareva cytokineresponseandotherdifferencesbetweencriticalphasesofsepsisassociatedsystemicinflammation
_version_	1718422428958326784

CYTOKINE RESPONSE AND OTHER DIFFERENCES BETWEEN CRITICAL PHASES OF SEPSIS-ASSOCIATED SYSTEMIC INFLAMMATION

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