A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up

Kazuhiko Yamamuro,1 Koji Okada,2 Naoko Kishimoto,1 Toyosaku Ota,1 Junzo Iida,3 Toshifumi Kishimoto1 1Department of Psychiatry, Nara Medical University School of Medicine, 2Department of Psychiatry, Jingumaecocorono-Clinic, 3Faculty of Nursing, Nara Medical University School of Medicine, Kashihara,...

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Autores principales:	Yamamuro K, Okada K, Kishimoto N, Ota T, Iida J, Kishimoto T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Obsessive-compulsive disorder Event related potentials P300 Mismatch negativity Improvement Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/78eff6dee0a548d39f49350f0a20bd0e
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spelling	oai:doaj.org-article:78eff6dee0a548d39f49350f0a20bd0e2021-12-02T02:50:20ZA longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up1178-2021https://doaj.org/article/78eff6dee0a548d39f49350f0a20bd0e2016-09-01T00:00:00Zhttps://www.dovepress.com/a-longitudinal-event-related-potential-pilot-study-of-adult-obsessive--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Kazuhiko Yamamuro,1 Koji Okada,2 Naoko Kishimoto,1 Toyosaku Ota,1 Junzo Iida,3 Toshifumi Kishimoto1 1Department of Psychiatry, Nara Medical University School of Medicine, 2Department of Psychiatry, Jingumaecocorono-Clinic, 3Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan Aim: Earlier brain imaging research studies have suggested that brain abnormalities in obsessive-compulsive disorder (OCD) normalize as clinical symptoms improve. However, although many studies have investigated event-related potentials (ERPs) in patients with OCD compared with healthy control subjects, it is currently unknown whether ERP changes reflect pharmacological and psychotherapeutic effects. As such, the current study examined the neurocognitive components of OCD to elucidate the pathophysiological abnormalities involved in the disorder, including the frontal-subcortical circuits.Methods: The Yale-Brown Obsessive-Compulsive Scale was used to evaluate 14 adult patients with OCD. The present study also included ten age-, sex-, and IQ-matched controls. The P300 and mismatch negativity (MMN) components during an auditory oddball task at baseline for both groups and after 1 year of treatment for patients with OCD were measured.Results: Compared with controls, P300 amplitude was attenuated in the OCD group at Cz and C4 at baseline. Pharmacotherapy and psychotherapy treatment for 1 year reduced OCD symptomology. P300 amplitude after 1 year of treatment was significantly increased, indicating normalization compared with baseline at Fz, Cz, C3, and C4. We found no differences in P300 latency, MMN amplitude, or MMN latency between baseline and after one year of treatment.Conclusion: ERPs may be a useful tool for evaluating pharmacological and cognitive behavioral therapy in adult patients with OCD. Keywords: obsessive-compulsive disorder, event-related potentials, P300, mismatch negativity, improvementYamamuro KOkada KKishimoto NOta TIida JKishimoto TDove Medical PressarticleObsessive-compulsive disorderEvent related potentialsP300Mismatch negativityImprovementNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2463-2471 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obsessive-compulsive disorder Event related potentials P300 Mismatch negativity Improvement Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Obsessive-compulsive disorder Event related potentials P300 Mismatch negativity Improvement Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yamamuro K Okada K Kishimoto N Ota T Iida J Kishimoto T A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
description	Kazuhiko Yamamuro,1 Koji Okada,2 Naoko Kishimoto,1 Toyosaku Ota,1 Junzo Iida,3 Toshifumi Kishimoto1 1Department of Psychiatry, Nara Medical University School of Medicine, 2Department of Psychiatry, Jingumaecocorono-Clinic, 3Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Japan Aim: Earlier brain imaging research studies have suggested that brain abnormalities in obsessive-compulsive disorder (OCD) normalize as clinical symptoms improve. However, although many studies have investigated event-related potentials (ERPs) in patients with OCD compared with healthy control subjects, it is currently unknown whether ERP changes reflect pharmacological and psychotherapeutic effects. As such, the current study examined the neurocognitive components of OCD to elucidate the pathophysiological abnormalities involved in the disorder, including the frontal-subcortical circuits.Methods: The Yale-Brown Obsessive-Compulsive Scale was used to evaluate 14 adult patients with OCD. The present study also included ten age-, sex-, and IQ-matched controls. The P300 and mismatch negativity (MMN) components during an auditory oddball task at baseline for both groups and after 1 year of treatment for patients with OCD were measured.Results: Compared with controls, P300 amplitude was attenuated in the OCD group at Cz and C4 at baseline. Pharmacotherapy and psychotherapy treatment for 1 year reduced OCD symptomology. P300 amplitude after 1 year of treatment was significantly increased, indicating normalization compared with baseline at Fz, Cz, C3, and C4. We found no differences in P300 latency, MMN amplitude, or MMN latency between baseline and after one year of treatment.Conclusion: ERPs may be a useful tool for evaluating pharmacological and cognitive behavioral therapy in adult patients with OCD. Keywords: obsessive-compulsive disorder, event-related potentials, P300, mismatch negativity, improvement
format	article
author	Yamamuro K Okada K Kishimoto N Ota T Iida J Kishimoto T
author_facet	Yamamuro K Okada K Kishimoto N Ota T Iida J Kishimoto T
author_sort	Yamamuro K
title	A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_short	A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_full	A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_fullStr	A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_full_unstemmed	A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_sort	longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/78eff6dee0a548d39f49350f0a20bd0e
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A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up

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