Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

Histone ubiquitination plays a critical role in the DNA damage response pathway. Here the authors reveal how RNF168 ubiquitinates the H2A family including noncanonical variants, H2AZ and macroH2A1/2, at the divergent N-terminal tail lysine residue.

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Detalles Bibliográficos
Autores principales: Jessica L. Kelliher, Kirk L. West, Qingguo Gong, Justin W. C. Leung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/78f4cd1bfa81402db000d570e1f392c6
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Sumario:Histone ubiquitination plays a critical role in the DNA damage response pathway. Here the authors reveal how RNF168 ubiquitinates the H2A family including noncanonical variants, H2AZ and macroH2A1/2, at the divergent N-terminal tail lysine residue.