Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia

Background Risk stratification for acute myeloid leukemia (AML) in children is a must in treatment strategy. This stratification is based on cytogenetic profiles, which are needed to determine proper management to gain better outcomes and reduce side effects of treatment. There is no such risk strat...

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Autores principales:	Hikari Ambara Sjakti, Gatot Djajadiman, Pustika Amalia Wahidiyat, Agus Kosasih, Iswari Setianingsih
Formato:	article
Lenguaje:	EN
Publicado:	Indonesian Pediatric Society Publishing House 2021
Materias:	t(8;21) inv(16) acute myeloid leukemia prognostic cytogenic Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/78f6bdb03031407eba1192944203fd82
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spelling	oai:doaj.org-article:78f6bdb03031407eba1192944203fd822021-11-29T02:29:22ZRole of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia0030-93112338-476X10.14238/pi61.6.2021.343-9https://doaj.org/article/78f6bdb03031407eba1192944203fd822021-11-01T00:00:00Zhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2816https://doaj.org/toc/0030-9311https://doaj.org/toc/2338-476XBackground Risk stratification for acute myeloid leukemia (AML) in children is a must in treatment strategy. This stratification is based on cytogenetic profiles, which are needed to determine proper management to gain better outcomes and reduce side effects of treatment. There is no such risk stratification available in Indonesia until now. Objective To evaluate the association between cytogenetic profiles of t(8,21) and inv(16) mutations with the complete response to induction phase of chemotherapy in pediatric AML. Methods A prospective study was conducted between year 2018 and 2020, involving children with AML from 4 pediatric oncology centers in Jakarta. Subjects were evaluated for cytogenetic profiles, especially t(8,21) and inv(16), as the favorable predictors for AML. Bone marrow remission was evaluated after 2 cycles of induction phase. The results were evaluated for remission rate and survival analysis. Results Karyotype data of 18 subjects were obtained. Translocation t(8;21) detected in 1 subject, and inv(16) mutation in 4 subjects. These two variables had no significant correlation with complete remission after induction phase. Nevertheless, favorable group had more tendencies to achieved remission than unfavorable group. Complete remission achieved in 61% subjects, 90% of theme had a relapse period with an average time 43 weeks. The relapse period in favorable group was shoter than in unfavorable group (34 weeks and 44 weeks, respectively). Conclusions This study shows that cytogenetic profiles of t(8;21) and inv(16) mutation can not be used as prognostic factors for complete remission after induction phase of chemotherapy in pediatric AML.Hikari Ambara SjaktiGatot DjajadimanPustika Amalia WahidiyatAgus KosasihIswari SetianingsihIndonesian Pediatric Society Publishing Housearticlet(8;21)inv(16)acute myeloid leukemiaprognosticcytogenicMedicineRPediatricsRJ1-570ENPaediatrica Indonesiana, Vol 61, Iss 6, Pp 343-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	t(8;21) inv(16) acute myeloid leukemia prognostic cytogenic Medicine R Pediatrics RJ1-570
spellingShingle	t(8;21) inv(16) acute myeloid leukemia prognostic cytogenic Medicine R Pediatrics RJ1-570 Hikari Ambara Sjakti Gatot Djajadiman Pustika Amalia Wahidiyat Agus Kosasih Iswari Setianingsih Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia
description	Background Risk stratification for acute myeloid leukemia (AML) in children is a must in treatment strategy. This stratification is based on cytogenetic profiles, which are needed to determine proper management to gain better outcomes and reduce side effects of treatment. There is no such risk stratification available in Indonesia until now. Objective To evaluate the association between cytogenetic profiles of t(8,21) and inv(16) mutations with the complete response to induction phase of chemotherapy in pediatric AML. Methods A prospective study was conducted between year 2018 and 2020, involving children with AML from 4 pediatric oncology centers in Jakarta. Subjects were evaluated for cytogenetic profiles, especially t(8,21) and inv(16), as the favorable predictors for AML. Bone marrow remission was evaluated after 2 cycles of induction phase. The results were evaluated for remission rate and survival analysis. Results Karyotype data of 18 subjects were obtained. Translocation t(8;21) detected in 1 subject, and inv(16) mutation in 4 subjects. These two variables had no significant correlation with complete remission after induction phase. Nevertheless, favorable group had more tendencies to achieved remission than unfavorable group. Complete remission achieved in 61% subjects, 90% of theme had a relapse period with an average time 43 weeks. The relapse period in favorable group was shoter than in unfavorable group (34 weeks and 44 weeks, respectively). Conclusions This study shows that cytogenetic profiles of t(8;21) and inv(16) mutation can not be used as prognostic factors for complete remission after induction phase of chemotherapy in pediatric AML.
format	article
author	Hikari Ambara Sjakti Gatot Djajadiman Pustika Amalia Wahidiyat Agus Kosasih Iswari Setianingsih
author_facet	Hikari Ambara Sjakti Gatot Djajadiman Pustika Amalia Wahidiyat Agus Kosasih Iswari Setianingsih
author_sort	Hikari Ambara Sjakti
title	Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia
title_short	Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia
title_full	Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia
title_fullStr	Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia
title_full_unstemmed	Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia
title_sort	role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia
publisher	Indonesian Pediatric Society Publishing House
publishDate	2021
url	https://doaj.org/article/78f6bdb03031407eba1192944203fd82
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Role of cytogenetic profiles as prognostic factors for complete remission after induction phase in acute myeloblastic leukemia

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