Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)

Abstract Chimpanzees are genetically and physiologically similar to humans. Several pharmacokinetic models of propofol are available and target controlled infusion (TCI) of propofol is established in humans, but not in chimpanzees. The purpose of this study was to investigate if human pharmacokineti...

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Autores principales:	T. Miyabe-Nishiwaki, A. Kaneko, A. Yamanaka, N. Maeda, J. Suzuki, M. Tomonaga, T. Matsuzawa, K. Muta, R. Nishimura, I. Yajima, D. J. Eleveld, A. R. Absalom, K. Masui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/78f7c10163e4481696e0b271349aa8bb
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spelling	oai:doaj.org-article:78f7c10163e4481696e0b271349aa8bb2021-12-02T14:01:36ZPropofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)10.1038/s41598-020-79914-72045-2322https://doaj.org/article/78f7c10163e4481696e0b271349aa8bb2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79914-7https://doaj.org/toc/2045-2322Abstract Chimpanzees are genetically and physiologically similar to humans. Several pharmacokinetic models of propofol are available and target controlled infusion (TCI) of propofol is established in humans, but not in chimpanzees. The purpose of this study was to investigate if human pharmacokinetic models can accurately predict propofol plasma concentration (Cp) in chimpanzees and if it is feasible to perform TCI in chimpanzees. Ten chimpanzees were anaesthetized for regular veterinary examinations. Propofol was used as an induction or maintenance agent. Blood samples were collected from a catheter in a cephalic vein at 3–7 time points between 1 and 100 min following the propofol bolus and/or infusion in five chimpanzees, or TCI in six chimpanzees. Cp was measured using high-performance liquid chromatography. The Marsh, Schnider and Eleveld human pharmacokinetic models were used to predict Cp for each case and we examined the predictive performances of these models using the Varvel criteria Median PE and Median APE. Median PE and Median APE for Marsh, Schnider and Eleveld models were within or close to the acceptable range. A human TCI pump was successfully maintained propofol Cp during general anesthesia in six chimpanzees. Human propofol pharmacokinetic models and TCI pumps can be applied in chimpanzees.T. Miyabe-NishiwakiA. KanekoA. YamanakaN. MaedaJ. SuzukiM. TomonagaT. MatsuzawaK. MutaR. NishimuraI. YajimaD. J. EleveldA. R. AbsalomK. MasuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q T. Miyabe-Nishiwaki A. Kaneko A. Yamanaka N. Maeda J. Suzuki M. Tomonaga T. Matsuzawa K. Muta R. Nishimura I. Yajima D. J. Eleveld A. R. Absalom K. Masui Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)
description	Abstract Chimpanzees are genetically and physiologically similar to humans. Several pharmacokinetic models of propofol are available and target controlled infusion (TCI) of propofol is established in humans, but not in chimpanzees. The purpose of this study was to investigate if human pharmacokinetic models can accurately predict propofol plasma concentration (Cp) in chimpanzees and if it is feasible to perform TCI in chimpanzees. Ten chimpanzees were anaesthetized for regular veterinary examinations. Propofol was used as an induction or maintenance agent. Blood samples were collected from a catheter in a cephalic vein at 3–7 time points between 1 and 100 min following the propofol bolus and/or infusion in five chimpanzees, or TCI in six chimpanzees. Cp was measured using high-performance liquid chromatography. The Marsh, Schnider and Eleveld human pharmacokinetic models were used to predict Cp for each case and we examined the predictive performances of these models using the Varvel criteria Median PE and Median APE. Median PE and Median APE for Marsh, Schnider and Eleveld models were within or close to the acceptable range. A human TCI pump was successfully maintained propofol Cp during general anesthesia in six chimpanzees. Human propofol pharmacokinetic models and TCI pumps can be applied in chimpanzees.
format	article
author	T. Miyabe-Nishiwaki A. Kaneko A. Yamanaka N. Maeda J. Suzuki M. Tomonaga T. Matsuzawa K. Muta R. Nishimura I. Yajima D. J. Eleveld A. R. Absalom K. Masui
author_facet	T. Miyabe-Nishiwaki A. Kaneko A. Yamanaka N. Maeda J. Suzuki M. Tomonaga T. Matsuzawa K. Muta R. Nishimura I. Yajima D. J. Eleveld A. R. Absalom K. Masui
author_sort	T. Miyabe-Nishiwaki
title	Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)
title_short	Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)
title_full	Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)
title_fullStr	Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)
title_full_unstemmed	Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)
title_sort	propofol infusions using a human target controlled infusion (tci) pump in chimpanzees (pan troglodytes)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/78f7c10163e4481696e0b271349aa8bb
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Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)

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