Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes)

Abstract Chimpanzees are genetically and physiologically similar to humans. Several pharmacokinetic models of propofol are available and target controlled infusion (TCI) of propofol is established in humans, but not in chimpanzees. The purpose of this study was to investigate if human pharmacokineti...

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Auteurs principaux: T. Miyabe-Nishiwaki, A. Kaneko, A. Yamanaka, N. Maeda, J. Suzuki, M. Tomonaga, T. Matsuzawa, K. Muta, R. Nishimura, I. Yajima, D. J. Eleveld, A. R. Absalom, K. Masui
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/78f7c10163e4481696e0b271349aa8bb
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