CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Choet al.show that TCR desensitisation correlates with cell-surface density of the phosphatas...

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Autores principales: Jae-Ho Cho, Hee-Ok Kim, Young-Jun Ju, Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Cheol-Heui Yun, Nunzio Bottini, Kylie Webster, Christopher C. Goodnow, Charles D. Surh, Cecile King, Jonathan Sprent
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/78f7f7ad99d8416b980d0d865134abd4
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spelling oai:doaj.org-article:78f7f7ad99d8416b980d0d865134abd42021-12-02T15:34:50ZCD45-mediated control of TCR tuning in naïve and memory CD8+ T cells10.1038/ncomms133732041-1723https://doaj.org/article/78f7f7ad99d8416b980d0d865134abd42016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13373https://doaj.org/toc/2041-1723Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Choet al.show that TCR desensitisation correlates with cell-surface density of the phosphatase CD45.Jae-Ho ChoHee-Ok KimYoung-Jun JuYoon-Chul KyeGil-Woo LeeSung-Woo LeeCheol-Heui YunNunzio BottiniKylie WebsterChristopher C. GoodnowCharles D. SurhCecile KingJonathan SprentNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jae-Ho Cho
Hee-Ok Kim
Young-Jun Ju
Yoon-Chul Kye
Gil-Woo Lee
Sung-Woo Lee
Cheol-Heui Yun
Nunzio Bottini
Kylie Webster
Christopher C. Goodnow
Charles D. Surh
Cecile King
Jonathan Sprent
CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
description Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Choet al.show that TCR desensitisation correlates with cell-surface density of the phosphatase CD45.
format article
author Jae-Ho Cho
Hee-Ok Kim
Young-Jun Ju
Yoon-Chul Kye
Gil-Woo Lee
Sung-Woo Lee
Cheol-Heui Yun
Nunzio Bottini
Kylie Webster
Christopher C. Goodnow
Charles D. Surh
Cecile King
Jonathan Sprent
author_facet Jae-Ho Cho
Hee-Ok Kim
Young-Jun Ju
Yoon-Chul Kye
Gil-Woo Lee
Sung-Woo Lee
Cheol-Heui Yun
Nunzio Bottini
Kylie Webster
Christopher C. Goodnow
Charles D. Surh
Cecile King
Jonathan Sprent
author_sort Jae-Ho Cho
title CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
title_short CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
title_full CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
title_fullStr CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
title_full_unstemmed CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
title_sort cd45-mediated control of tcr tuning in naïve and memory cd8+ t cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/78f7f7ad99d8416b980d0d865134abd4
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